Prolactin Receptor Gene Polymorphisms Are Associated with Gestational Diabetes
Prolactin Receptor Gene Polymorphisms Are Associated with Gestational Diabetes
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DOI：
10.1089/gtmb.2013.0009
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发表时间：
2013-07-01
影响因子：
1.4
通讯作者：
Francis, Gary L.
中科院分区：
文献类型：
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作者：
Le, Trang N.;Elsea, Sarah H.;Francis, Gary L.
目的：人胎盘催乳素（hPL）通过催乳素受体（PRLR）作用于母体β细胞，介导正常妊娠期间β细胞质量和功能的增加。hPL和PRLR之间的这种相互作用对于维持正常的葡萄糖稳态和解决妊娠增加的代谢需求至关重要。鉴于PRLR-hPL轴在胰岛细胞适应妊娠中的重要性，我们假设PRLR基因的遗传变异可能影响妊娠期糖尿病（GDM）的发生风险。对96例妊娠期糖尿病母亲和96例正常母亲的DNA样本进行PRLR基因8个单核苷酸多态性（SNPs）基因分型。结果：在分析的两个SNPs中发现了显着的关联。PRLR SNPs rs 10068521和rs 9292578的次要等位基因在GDM病例中比对照组更常见，并且与携带次要等位基因的GDM风险增加2.36倍相关。结论：在智利人群中，PRLR基因5' UTR和启动子区的SNPs与GDM风险增加相关。
Aims: Human placental lactogen (hPL) acts via the prolactin receptor (PRLR) on maternal beta-cells to mediate increases in beta-cell mass and function during normal pregnancy. This interaction between hPL and PRLR is essential to maintain normal glucose homeostasis and to address the increased metabolic demands of pregnancy. Given the importance of the PRLR-hPL axis in pancreatic islet cell adaptation to pregnancy, we hypothesized that genetic variation in the PRLR gene could influence risk of development of gestational diabetes mellitus (GDM). DNA samples from 96 mothers affected by GDM and 96 unaffected cases were genotyped for 8 selected single nucleotide polymorphisms (SNPs) in PRLR. Results: Significant associations were identified in two SNPs analyzed. The minor alleles of PRLR SNPs rs10068521 and rs9292578 were more frequently observed in GDM cases than controls and were associated with a 2.36-fold increased risk for GDM in those carrying the minor allele. Conclusion: SNPs of the PRLR gene 5' UTR and promoter region are associated with increased risk for GDM in a population of Chilean subjects.