Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy
Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy
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DOI：
10.2169/internalmedicine.55.5473
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发表时间：
2016-01-01
影响因子：
1.2
通讯作者：
Wada, Takashi
中科院分区：
文献类型：
--
作者：
Shimizu, Miho;Furuichi, Kengo;Wada, Takashi
目的 评估活检证实的糖尿病肾病 2 型糖尿病患者血清自分泌运动因子（ATX）水平与临床和病理参数以及长期肾脏结局之间的关系。 方法 在这项回顾性单中心队列研究中，收集 38 例活检证实的糖尿病肾病的日本 2 型糖尿病患者肾活检时的血清样本。采用特异性夹心酶免疫分析法测定血清ATX水平。结果多元线性回归分析显示尿蛋白排泄量与血清ATX水平独立相关。此外，与血清ATX水平低于中位值的患者相比，血清ATX水平高于中位值的患者表现出更严重的弥漫性病变、结节性病变和小动脉透明变性。然而，高血清 ATX 水平与肾脏复合事件数量的增加（需要透析或估计肾小球滤过率 (eGFR) 较基线下降 50%）无关。 结论 合并糖尿病肾病的 2 型糖尿病患者的血清 ATX 水平与蛋白尿和糖尿病肾损伤相关，尽管血清 ATX 水平未被确定为肾脏结局的预测指标。
Objective We evaluated the relationships between the serum autotaxin (ATX) levels and the clinical and pathological parameters, as well as the long-term renal outcome, in type 2 diabetic patients with biopsyproven diabetic nephropathy.Methods In this retrospective single-center cohort study, serum samples were collected from 38 Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy at the time of renal biopsy. The serum ATX levels were measured using a specific sandwich enzyme immunoassay.Results A multivariate linear regression analysis revealed the urinary protein excretion to be independently associated with the serum ATX levels. In addition, patients with serum ATX levels above the median showed more advanced diffuse lesions, nodular lesions and arteriolar hyalinosis compared to those with serum ATX levels below the median. However, high serum ATX levels were not associated with any increase in the number of renal composite events [a need for dialysis or a 50% decline in the estimated glomerular filtration rate (eGFR) from baseline].Conclusion The serum ATX levels in type 2 diabetic patients with diabetic nephropathy were associated with proteinuria and diabetic kidney lesions, although the serum ATX levels were not identified to be a predictive indicator for the renal outcome.