The relationship between adiposity, bone density and microarchitecture is maintained in young women irrespective of diabetes status
The relationship between adiposity, bone density and microarchitecture is maintained in young women irrespective of diabetes status
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DOI：
10.1111/cen.13410
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发表时间：
2017-10-01
影响因子：
3.2
通讯作者：
Ahmed, S. F.
中科院分区：
文献类型：
--
作者：
Abdalrahaman, N.;McComb, C.;Ahmed, S. F.
对17例1型糖尿病(T1 DM)患者和9例年龄匹配的健康女性(中位年龄22.6岁，17.4岁，23.8岁)进行3T磁共振成像和磁共振波谱检查，评价腹部肥胖、胫骨微结构和椎体骨髓肥厚(BMA)。其他措施包括基于DXA的全身(TB)、股骨颈(FN)和腰椎(LS)骨密度(BMD)和脂肪质量(FM)的评估。结果尽管T1 DM患者的BMI和BMA与对照组相似，但MRI上她们的内脏和皮下肥胖程度更高(P
BackgroundThe relationship between bone health and adiposity and how it may be affected in people with chronic metabolic conditions is complex.MethodsSeventeen women with type 1 diabetes mellitus (T1DM) and nine age-matched healthy women with a median age of 22.6years (range, 17.4, 23.8) were studied by 3T MRI and MR spectroscopy to assess abdominal adiposity, tibial bone microarchitecture and vertebral bone marrow adiposity (BMA). Additional measures included DXA-based assessments of total body (TB), femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) and fat mass (FM).ResultsAlthough women with T1DM had similar BMI and BMA to the controls, they had higher visceral and subcutaneous adiposity on MRI (P