Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects
Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects
复制标题
DOI：
10.1016/s0091-3057(03)00072-8
复制
发表时间：
2003-04-01
影响因子：
3.6
通讯作者：
Bellinger, LL
中科院分区：
文献类型：
--
作者：
Kerins, CA;Carlson, DS;Bellinger, LL
建立一个有效的动物模型来研究颞下颌关节（TMJ）疼痛是非常困难的。利用完全弗氏佐剂（CIA）诱导TMJ炎症，我们最近发现饮食模式分析可以作为研究动物模型TMJ疼痛的无创生物标志物。本研究的目的是通过确定布洛芬（ibuprofen， IBU）治疗是否能逆转cfa诱导的TMJ炎症/疼痛的各个方面，进一步验证我们的动物模型。在第一项试验中，使用48只雄性大鼠，在第二项试验中，使用32只切除卵巢的雌性大鼠，给予17 -雌二醇替代品。将大鼠分为四组：对照组（CON - CON）；控制+伊布·(CON +伊布·);CFA-CON;和CFA +伊布·。在男性试验中，注射CFA (P
Establishing a valid animal model to study temporomandibular joint (TMJ) pain has proven extremely difficult. Using complete Freund's adjuvant (CIA) to induce TMJ inflammation, we recently showed that meal pattern analysis could be used as a noninvasive biological marker to study TMJ pain in an animal model. The purpose of this study was to further validate our animal model by determining whether aspects of CFA-induced TMJ inflammation/pain are reversed with ibuprofen (IBU) treatment. In the first trial, 48 male rats were used and in the second trial, 32 female ovariectomized rats, given 17beta-estradiol replacement, were used. The rats were assigned to one of four groups: control (CON - CON); control+IBU (CON+IBU); CFA-CON; and CFA+IBU. In the male trial, CFA injection (P