Method for Accessing Nitrogen-Containing, B-Heteroaryl-Substituted 2,1-Borazaronaphthalenes.
Method for Accessing Nitrogen-Containing, B-Heteroaryl-Substituted 2,1-Borazaronaphthalenes.
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DOI：
10.1021/acs.joc.6b02574
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发表时间：
2017-01-06
期刊：
影响因子：
--
通讯作者：
Molander GA
中科院分区：
文献类型：
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作者：
Davies GH;Zhou ZZ;Jouffroy M;Molander GA
氮杂硼杂环基序通过用B-N键取代C=C键提供芳香族系统的模拟物。特别是，2，1-硼氮杂萘，可通过稳健的合成方法和随后的官能化，提供了一个理想的平台，用于各种应用。然而，这种原型的亚结构的范围受到了缺乏含氮杂芳基的限制。在这项研究中，改进了反应条件，以提供更广泛的亚结构。
The azaborine motif provides a mimic of aromatic systems through replacement of a C=C bond with a B–N bond. In particular, 2,1-borazaronaphthalenes, accessible through robust methods of synthesis and subsequent functionalization, afford an ideal platform to use for a variety of applications. However, the scope of substructures for this archetype has been limited by the lack of nitrogen-containing heteroaryls that can be incorporated within them. In this study, modified reaction conditions were developed to provide access to a wider range of substructures.