The structure of the mammalian centromere
The structure of the mammalian centromere
复制标题
哺乳动物着丝粒的结构
作者：
J. Rattner
哺乳动物着丝粒是一个多功能的染色体结构域，其复杂性反映在其高级结构、DNA序列组织和蛋白质组成中。着丝粒在细胞分裂过程中起着重要作用，它是染色体与有丝分裂纺锤体整合的位点，是负责染色体运动的机械化学马达的位点，也是姐妹染色单体之间相互作用的主要和最后一点。最近的研究集中在描述着丝粒的组成部分，并建立它们与其功能的关系。以下简要回顾总结了最近这项工作的某些方面。
The mammalian centromere is a multifunctional chromosomal domain with a complexity that is reflected in its higher order structure, DNA sequence organization and protein composition. The centromere plays a major role during cell division where it functions as the site for the integration of the chromosome with the mitotic spindle, the site of the mechanochemical motor responsible for the movement of chromosomes and the major and last point of interaction between sister chromatids. Recent studies have focused on characterizing the components of the centromere and establishing their relationship to its function. The following brief review summarizes some selected aspects of this recent work.