Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults
Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults
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DOI：
10.1002/lary.22480
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发表时间：
2012-03-01
期刊：
影响因子：
2.6
通讯作者：
Chau, Justin K.
中科院分区：
文献类型：
--
作者：
Lin, Rui Jun;Krall, Randall;Chau, Justin K.
目的/假设：回顾有关突发性神经性耳聋(SSNHL)在成人人群中潜在危险因素的医学文献证据。研究设计：系统回顾前瞻性和回顾性研究；病例对照研究的荟萃分析。方法：除了进行手动参考检索外，三位研究人员独立审查了MEDLINE(1950年1月1日至2010年11月30日)、Embase(1980年1月1日至2010年11月30日)和循证医学综述数据库。研究包括随机对照试验、前瞻性队列研究、连续/非连续病例系列，以及对SSNHL有明确定义的回顾。研究人员单独提取了有关患者信息和假定的风险因素的数据。结果：22篇文章符合纳入标准。心血管危险因素(吸烟、饮酒增加)似乎与发展为SSNHL的高风险相关。低水平的血清叶酸也可能是一个危险因素。多项研究发现因子V Leiden和MTHFR基因多态性在SSNHL患者中发生的频率更高，提示这些遗传的亲血栓原突变可能是SSNHL的独立危险因素。结论：获得性和遗传性心血管危险因素可能与SSNHL的发病风险增加有关。
Objectives/Hypothesis: To review the medical literature evidence of potential risk factors for sudden sensorineural hearing loss (SSNHL) in the adult general population.Study Design: Systematic review of prospective and retrospective studies; meta-analysis of case-controlled studies.Methods: Three researchers independently reviewed MEDLINE (January 1, 1950-November 30, 2010), Embase (January 1, 1980-November 30, 2010), and Evidence-Based Medicine Reviews databases in addition to conducting a manual reference search. Randomized controlled trials, prospective cohort studies, consecutive/nonconsecutive case series, and retrospective reviews in which a clear definition of SSNHL was stated were included in the study. Researchers individually extracted data regarding patient information and the presumed risk factors. Discrepancies were resolved by mutual consensus.Results: Twenty-two articles met the inclusion criteria. Cardiovascular risk factors (smoking, increased alcohol consumption) appeared to be associated with a higher risk of developing SSNHL. A low level of serum folate may also be implicated as a risk factor. Factor V Leiden and MTHFR gene polymorphisms were found to occur more frequently in patients with SSNHL in several studies, suggesting these inherited prothrombophilic mutations could be independent risk factors of SSNHL.Conclusions: Acquired and inherited cardiovascular risk factors appeared to be associated with an increased risk of developing SSNHL.