Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma
Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma
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DOI：
10.1111/j.1349-7006.2007.00570.x
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发表时间：
2007-10-01
期刊：
影响因子：
5.7
通讯作者：
Unno, Michiaki
中科院分区：
文献类型：
--
作者：
Muto, Mitsuhisa;Onogawa, Tohru;Unno, Michiaki
人类肝脏特异性有机阴离子转运蛋白-2 （LST-2/OATP8/SLCO1B3）已被证明在多种胃肠道癌中表达，并在多种内源性和外源性阴离子化合物（包括胆汁酸、偶联类固醇和激素）摄取到人类肝脏的肝细胞中发挥关键作用。然而，LST-2在人类肿瘤中的生物学意义尚不清楚。在本研究中，我们采用免疫组织化学方法检测了LST-2在102例乳腺癌中的表达，并将其与各种临床病理参数相关联，以探讨LST-2可能的生物学和临床意义。51例（50.0%）检测到LST-2免疫反应性；在51例阳性病例中，LST-2免疫反应性与肿瘤大小呈负相关（P = 0.0289）。此外，单因素（P = 0.02和P = 0.01）和多因素（P = 0.03和P = 0.01）分析显示，LST-2免疫反应性与复发风险降低和预后改善显著相关。在雌激素受体阳性组中，lst -2阳性患者预后良好。考虑到LST-2转运硫酸雌酮3，这些结果提示LST-2过表达与乳腺癌激素依赖性生长机制有关。我们目前的研究结果表明，LST-2免疫反应性是人类乳腺癌的一个强有力的预后因素。
Human liver-specific organic anion transporter-2 (LST-2/OATP8/SLCO1B3) has been demonstrated to be expressed in various gastrointestinal carcinomas and also to play pivotal roles in the uptake of a wide variety of both endogenous and exogenous anionic compounds, including bile acids, conjugated steroids and hormones, into hepatocytes in the human liver. However, the biological significance of LST-2 in human carcinomas remains unknown. In the present study, we examined the expression of LST-2 in 102 cases of breast carcinoma using immunohistochemistry and correlated the findings with various clinicopathological parameters in order to examine the possible biological and clinical significance of LST-2. LST-2 immunoreactivity was detected in 51 cases (50.0%); of these 51 positive cases, LST-2 immunoreactivity was inversely correlated with tumor size (P = 0.0289). In addition, LST-2 immunoreactivity was significantly associated with a decreased risk of recurrence and improved prognosis by both univariate (P = 0.02 and P = 0.01) and multivariate (P = 0.03 and P = 0.01) analyses. In the estrogen receptor-positive groups, the LST-2-positive patients showed good prognoses. Considering that LST-2 transports estrone-3-sulfate, these results suggest that LST-2 overexpression is associated with a hormone-dependent growth mechanism of the breast cancer. The results of our present study demonstrate that LST-2 immunoreactivity is a potent prognostic factor in human breast cancer.