On the need for comprehensive validation of deformable image registration, investigated with a novel 3-dimensional deformable dosimeter.
On the need for comprehensive validation of deformable image registration, investigated with a novel 3-dimensional deformable dosimeter.
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DOI：
10.1016/j.ijrobp.2013.05.045
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发表时间：
2013-10-01
影响因子：
7
通讯作者：
Oldham, Mark
中科院分区：
文献类型：
--
作者：
Juang, Titania;Das, Shiva;Adamovics, John;Benning, Ron;Oldham, Mark
可变形图像配准（REMPERATURE）算法可以实现多部分剂量跟踪和改善的治疗反应评估，但必须研究这些方法的准确性。本研究介绍并评估了一种新型可变形3D剂量测定系统（Presage-Def/Optical-CT）及其在研究商业DIR包中剂量变形准确性方面的应用。Presage-Def是一种新型的剂量测定材料，由弹性聚氨酯基质和辐射变色隐色染料组成。使用标准技术表征放射性和机械性能。通过比较在有和没有27%侧向压缩的情况下辐照的剂量计之间的剂量分布，评价剂量跟踪可行性。5 mm正方形视野的棋盘格计划能够使用3D剂量测定法精确测量真实变形。预测的变形是从一个商业的ARMA算法。Presage-Def呈线性剂量反应，灵敏度为0.0032 ΔOD/（戈伊·cm）。质量密度为1.02 g/cm 3，有效原子序数在宽能量范围（0.03-10 MeV）内为水的1.5%，表明水的等效性良好。弹性特性接近肝组织，在0.233-303 kPa的应力范围内杨氏模量为13.5-887 kPa，泊松比为0.475（SE=0.036）。的前-Def/光学-CT系统成功地成像的非变形和变形的剂量分布与各向同性分辨率为1毫米。预测变形的3D剂量分布的比较，确定在商业的放射治疗算法的不准确性。虽然外部轮廓精确变形（亚毫米精度），但体积剂量变形较差。经鉴定，靶板射野定位和尺寸误差分别高达9 mm和14 mm，3D DIR变形剂量伽马通过率仅为γ3%/3 mm = 60.0%。压力-Def/光学-CT系统显示出对CT算法准确性进行全面调查的强大潜力。在评价的条件下，发现商业试验中的实质性错误。这项工作强调了在临床实施之前仔细验证并行算法的至关重要性。
Deformable image registration (DIR) algorithms may enable multi-fraction dose tracking and improved treatment response assessment, but the accuracy of these methods must be investigated. This study introduces and evaluates a novel deformable 3D dosimetry system (Presage-Def/Optical-CT) and its application toward investigating the accuracy of dose deformation in a commercial DIR package. Presage-Def is a new dosimetry material consisting of an elastic polyurethane matrix doped with radiochromic leuco dye. Radiological and mechanical properties were characterized using standard techniques. Dose-tracking feasibility was evaluated by comparing dose distributions between dosimeters irradiated with and without 27% lateral compression. A checkerboard plan of 5 mm square fields enabled precise measurement of true deformation using 3D dosimetry. Predicted deformation was determined from a commercial DIR algorithm. Presage-Def exhibited a linear dose response with sensitivity of 0.0032 ΔOD/(Gy·cm). Mass density is 1.02 g/cm3 and effective atomic number is within 1.5% of water over a broad (0.03–10 MeV) energy range, indicating good water-equivalence. Elastic characteristics were close to liver tissue, with Young’s modulus of 13.5–887 kPa over a stress range of 0.233–303 kPa, and Poisson’s ratio of 0.475 (SE=0.036). The Presage-Def/Optical-CT system successfully imaged the non-deformed and deformed dose distributions with isotropic resolution of 1 mm. Comparison with the predicted deformed 3D dose distribution identified inaccuracies in the commercial DIR algorithm. While external contours were accurately deformed (sub-millimeter accuracy), volumetric dose deformation was poor. Checkerboard field positioning and dimension errors of up to 9 and 14 mm respectively were identified, and the 3D DIR-deformed dose gamma passing rate was only γ3%/3mm=60.0%. The Presage-Def/Optical-CT system shows strong potential for comprehensive investigation of DIR algorithm accuracy. Substantial errors in a commercial DIR were found in the conditions evaluated. This work highlights the critical importance of careful validation of DIR algorithms prior to clinical implementation.
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影响因子：
3.5
作者：
Yang D;Li H;Low DA;Deasy JO;El Naqa I
通讯作者：
El Naqa I
影响因子：
3.1
作者：
Thornqvist, Sara;Petersen, Jorgen B. B.;Muren, Ludvig Paul
通讯作者：
Muren, Ludvig Paul
影响因子：
3.5
作者：
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通讯作者：
Baldock, Clive
影响因子：
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作者：
Sparks, Jessica L.;Dupaix, Rebecca B.
通讯作者：
Dupaix, Rebecca B.
影响因子：
3.8
作者：
Yeo, U. J.;Taylor, M. L.;Franich, R. D.
通讯作者：
Franich, R. D.