Correlation Between Pupil Diameter and Angle Configuration in the Dark Room Provocative Test
Correlation Between Pupil Diameter and Angle Configuration in the Dark Room Provocative Test
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DOI：
10.1097/ijg.0b013e3181eda73a
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发表时间：
2011-08-01
影响因子：
2
通讯作者：
Mu, Dapeng
中科院分区：
文献类型：
--
作者：
Li, Dejiao;Wang, Ningli;Mu, Dapeng
目的：研究暗室刺激试验中瞳孔直径变化与前房角形态的关系。方法：选取70例初角闭合疑似患者（研究组）和40例正常人（对照组）作为研究对象。利用前段光学相干断层扫描（AS-OCT），我们测量了黑暗适应3分钟和1.5小时时的前房角结构和瞳孔直径。结果：在研究组中，暗适应3分钟（3.9 +/- 2.3）时闭合角段的平均数量显著（P < 0.001）高于室内光照条件下（2.6 +/- 2.2）或暗适应1.5小时（3.1 +/- 2.1），后两者之间差异无统计学意义（P < 0.05）。实验组瞳孔直径在暗适应3分钟时与闭角节数显著相关（P < 0.01），在暗适应1.5小时时与闭角节数无显著相关（P = 0.13）。定义为增加闭合角度片段的数量，暗室测试在3分钟的参与者中呈阳性的人数明显高于在1.5小时的黑暗适应中[44（63%）对31（44%）只眼睛；P < 0.05]。最终眼压与3分钟时评估的角度配置段的相关性（相关系数r(2) = 0.33）优于暗适应1.5小时时（相关系数r(2) = 0.21）。结论：经过3分钟的短期暗适应后，as - oct对前房角结构的评估比经过长期暗适应后评估更可靠，可用于识别原发性闭角的嫌疑。
Purpose: To study the associations between changes in pupil diameter and in the anterior chamber angle configuration during the dark room provocative test.Methods: The study included 70 suspects of primary angle closure (study group) and 40 normal participants (control group). Using anterior-segment optical coherence tomography (AS-OCT), we measured the anterior chamber angle configuration and pupil diameter at 3 minutes and at 1.5 hours of dark adaptation.Results: In the study group, the mean number of closed angle segments was significantly (P < 0.001) higher at 3 minutes of dark adaptation (3.9 +/- 2.3) than at room light conditions (2.6 +/- 2.2) or at 1.5 hours of dark adaptation (3.1 +/- 2.1), with no statistically significant (P > 0.05) difference between the 2 latter values. In the study group, the pupil diameter was significantly associated with the number of closed angle segments at 3 minutes of dark adaptation (P < 0.01), but not at 1.5 hours of dark adaptation (P = 0.13). Defined as an increased number of closed angle segments, the dark room test was positive in a significantly higher number of participants at 3 minutes than at 1.5 hours of dark adaptation [44 (63%) eyes vs. 31 (44%) eyes; P < 0.05]. Final interocular pressure was statistically better correlated with the angle configuration segments assessed at 3 minutes (correlation coefficient r(2) = 0.33) than at 1.5 hours of dark adaptation (r(2) = 0.21).Conclusions: After short-term dark adaptation of 3 minutes, the assessment of the anterior chamber angle configuration by AS-OCT is more reliable than as if carried out after a long-term dark adaptation and may be used to identify suspects of primary angle closure.