Clinical Characteristics of Asymptomatic Patients with COVID-19: A Nationwide Cohort Study in South Korea
Clinical Characteristics of Asymptomatic Patients with COVID-19: A Nationwide Cohort Study in South Korea
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DOI：
10.1016/j.ijid.2020.08.001
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发表时间：
2020-10-01
影响因子：
8.4
通讯作者：
Chang, Tae Ik
中科院分区：
文献类型：
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作者：
Jung, Chan-Young;Park, Haeyong;Chang, Tae Ik
目的：描述韩国确诊的COVID-19无症状和有症状患者的临床特征。方法：数据来自韩国国家健康保险服务数据库，该数据库与韩国疾病控制和预防中心的数据相关联。结果：在10，237例患者中，（平均[SD]年龄，45.0 [19.8]岁; 60.1%为女性），6，350例（62.0%）患者无症状，3，887例（38.0%）患者有症状。无症状和有症状患者的平均年龄和中位年龄相似。值得注意的是，我们观察到年龄组与无症状患者比例之间存在U形关联，40-49岁年龄组的最低点为57.3%。这种U型分布在男性和女性之间基本相似。无症状个体的总体患病率更高，无论性别、居住地区、收入水平和共病情况如何。结论：在这个超过10，000名COVID-19患者的全国队列中，韩国超过60%的病例在诊断时报告没有症状。应紧急考虑扩大接触者追踪和检测的标准，以在症状出现前捕捉潜在的传播，为COVID-19控制策略提供信息。(C)2020作者（S）由爱思唯尔有限公司代表国际传染病学会出版。
Objectives: To delineate clinical characteristics of asymptomatic and symptomatic patients confirmed with COVID-19 in South Korea.Methods: Data were obtained from the Korean National Health Insurance Service database linked to the Korea Centers for Disease Control and Prevention data.Results: Among 10,237 patients (mean [SD] age, 45.0 [19.8] years; 60.1% female) who met the eligibility criteria for the study, 6,350 (62.0%) patients were asymptomatic, and 3,887(38.0%) patients were symptomatic. The mean and median age were similar between asymptomatic and symptomatic patients. Notably, we observed a U-shaped association between age group and the proportion of asymptomatic patients, with the nadir at 57.3% in the 40-49 age group. This U-shaped distribution was largely similar between men and women. The overall prevalence of asymptomatic individuals was higher, regardless of sex, residential area, income levels, and comorbid conditions.Conclusions: In this national cohort of over 10,000 patients with COVID-19, more than 60% of all cases in South Korea reported no symptoms at the time of diagnosis. Expanding criteria for contact tracing and testing to capture potential transmission before symptom onset should be urgently considered to inform control strategies for COVID-19. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.