Cicatricial ectropion secondary to 5-fluorouracil therapy.
Cicatricial ectropion secondary to 5-fluorouracil therapy.
复制标题
5-氟尿嘧啶治疗继发的瘢痕性外翻。
DOI：
--
复制
发表时间：
1977
期刊：
影响因子：
--
通讯作者：
J. Mccracken
中科院分区：
文献类型：
--
作者：
D. Straus;F. Mausolf;R. Ellerby;J. Mccracken
描述了四例因长期全身给予 5-氟尿嘧啶而继发的瘢痕外翻病例。 1 名患者的外翻通过保守治疗和停用 5-FU 得到解决。另一名患者最终出现外翻，并在其消退前死亡。 2 名患者的外翻手术修复未能成功缓解结膜症状，同时继续使用 5-FU。随着使用 5-FU 的辅助化疗方案的延长，这种并发症的出现频率可能会增加。应尝试保守治疗，并向有此问题的患者保证，停止使用 5-FU 后症状将会消失。
Four cases of cicatricial ectropion secondary to prolonged systemic administration of 5-fluorouracil are described. In 1 patient ectropion resolved with conservative treatment and discontinuation of 5-FU. Another patient developed the ectropion terminally and died before its resolution. In 2 patients surgical repair of the ectropion was unsuccessful in relieving conjunctival symptoms while 5-FU was continued. With prolonged adjuvant chemotherapy programs utilizing 5-FU, this complication may be seen with increasing frequency. Conservative management should be attempted, and patients with this problem should be reassured that symptoms will resolve when 5-FU is stopped.