MEASUREMENT OF WALL SHEAR STRESS EXERTED BY FLOWING BLOOD IN THE HUMAN CAROTID ARTERY: ULTRASOUND DOPPLER VELOCIMETRY AND ECHO PARTICLE IMAGE VELOCIMETRY
MEASUREMENT OF WALL SHEAR STRESS EXERTED BY FLOWING BLOOD IN THE HUMAN CAROTID ARTERY: ULTRASOUND DOPPLER VELOCIMETRY AND ECHO PARTICLE IMAGE VELOCIMETRY
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DOI：
10.1016/j.ultrasmedbio.2018.02.013
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发表时间：
2018-07-01
影响因子：
2.9
通讯作者：
Shandas, Robin
中科院分区：
文献类型：
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作者：
Gates, Phillip E.;Gurung, Arati;Shandas, Robin
血管内皮细胞对血流施加的壁剪切力(WSS)非常敏感。WSS是血管疾病病理生理学的重要组成部分，通常采用中心线超声多普勒测速仪(UDV)进行评估。然而，这种方法的准确性是不确定的。我们之前已经验证了使用一种新的基于超声的粒子图像测速技术(ECHO PIV)来计算二维速度矢量场，该矢量场可以很容易地转换为WSS数据。我们比较了27名健康受试者颈总动脉UDV和ECHO PIV的WSS数据。与ECHO PIV相比，UDV时均WSS较低(28+/-35%)。ECHO PIV显示，这是由于血流速度分布的时空变化，而不是假设血流是稳定的，速度曲线在整个心脏周期是抛物线的。UDV对WSS的低估以收缩高峰时最大(118+/-16%)，舒张期最小(4.3+/-46%)。UDV方法低估了收缩加速和减速的WSS(68+/-30%和24+/-51%)，而高估了WSS的舒张末(-44+/-55%)。我们的数据表明，WSS的UDV估计提供了关于WSS的有限且在很大程度上不准确的信息，并且复杂的时空血流模式与关于动脉中血流的传统假设不太相符。ECHO PIV派生的WSS提供了关于影响血管内皮细胞病理生理的这一重要但鲜为人知的刺激的详细信息。(C)2018年世界医学和生物学超声联合会。版权所有。
Vascular endothelial cells lining the arteries are sensitive to wall shear stress (WSS) exerted by flowing blood. An important component of the pathophysiology of vascular diseases, WSS is commonly estimated by centerline ultrasound Doppler velocimetry (UDV). However, the accuracy of this method is uncertain. We have previously validated the use of a novel, ultrasound-based, particle image velocimetry technique (echo PIV) to compute 2-D velocity vector fields, which can easily be converted into WSS data. We compared WSS data derived from UDV and echo PIV in the common carotid artery of 27 healthy participants. Compared with echo PIV, time-averaged WSS was lower using UDV (28 +/- 35%). Echo PIV revealed that this was due to considerable spatiotemporal variation in the flow velocity profile, contrary to the assumption that flow is steady and the velocity profile is parabolic throughout the cardiac cycle. The largest WSS underestimation by UDV was found during peak systole (118 +/- 16%) and the smallest during mid-diastole (4.3 +/- 46%). The UDV method underestimated WSS for the accelerating and decelerating systolic measurements (68 +/- 30% and 24 +/- 51%), whereas WSS was overestimated for end-diastolic measurements (-44 +/- 55%). Our data indicate that UDV estimates of WSS provided limited and largely inaccurate information about WSS and that the complex spatiotemporal flow patterns do not fit well with traditional assumptions about blood flow in arteries. Echo PIV-derived WSS provides detailed information about this important but poorly understood stimulus that influences vascular endothelial pathophysiology. (c) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.