A longitudinal study of the association of the eicosapentaenoic acid/arachidonic acid ratio derived from fish consumption with the serum lipid levels: a pilot study
A longitudinal study of the association of the eicosapentaenoic acid/arachidonic acid ratio derived from fish consumption with the serum lipid levels: a pilot study
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鱼类消费中二十碳五烯酸/花生四烯酸比率与血清脂质水平关联的纵向研究：一项试点研究
DOI：
10.1007/s00380-018-1226-1
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发表时间：
2018
影响因子：
1.5
通讯作者：
Matsumoto Naoya
中科院分区：
文献类型：
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作者：
Tani Shigemasa;Matsuo Rei;Matsumoto Naoya
已经证明，经常食用鱼类与动脉粥样硬化性心血管疾病（ASCVD）的死亡率降低有关。然而，数据是稀缺的相关性在血清二十碳五烯酸/花生四烯酸（EPA/AA）的比例与经常食用鱼类和血脂谱变量的变化之间的变化。本研究设计为一项以医院为基础的纵向研究，旨在研究具有一个或多个ASCVD危险因素的患者血清EPA/AA比值变化与血脂水平变化之间的关系。在475例随访至少1年的患者中，校正ASCVD风险因素后进行的单变量和多变量回归分析显示，EPA/AA比值的绝对变化EPA/AA比值与血清低密度脂蛋白胆固醇（LDL-C）水平的变化独立相关（β= − 0.129，p = 0.005），甘油三酯（TG）（β= − 0.108，p = 0.019），非高密度脂蛋白胆固醇（非HDL-C）（β= − 0.149，p = 0.001）和TG/HDL-C比值（LDL颗粒大小的标志物）（β= − 0.104，p = 0.02），而与任何其他脂质参数无关。另一方面，DHA/AA比值与血清HDL-C水平呈负相关，与TG/HDL-C比值呈正相关，可能促进动脉粥样硬化的发展。结果表明，EPA/AA比值的增加可能与血清LDL-C、TG和非HDL-C水平的降低以及TG/HDL-C比值的增加相关，这代表了LDL颗粒尺寸的增加，所有这些都在ASCVD的发展中起作用。高EPA/AA比例，而不是DHA/AA比例，来自鱼类消费可能会降低ASCVD的风险，通过降低动脉粥样硬化的发展风险。临床试验注册信息：UMIN（ http://www.umin.ac.jp/ ），研究ID：UMIN 000010603。
It has been demonstrated that regular fish consumption is associated with a reduced mortality from atherosclerotic cardiovascular disease (ASCVD). However, data are scarce regarding the correlation between the changes in the serum eicosapentaenoic acid/arachidonic acid (EPA/AA) ratio associated with regular fish consumption and the changes in the serum lipid profile variables. This study was designed as a hospital-based longitudinal study to investigate the relationship between the changes in the serum EPA/AA ratio and changes of the serum lipid levels in patients with one or more risk factors for ASCVD. In 475 patients followed-up for at least 1 year, univariable and multivariable regression analyses conducted after adjustments for the risk factors of ASCVD revealed that the absolute change of the EPA/AA ratio (∆EPA/AA ratio) was independently and significantly associated with the changes of the serum levels of low-density lipoprotein cholesterol (LDL-C) (β= − 0.129,p= 0.005), triglyceride (TG) (β= − 0.108,p= 0.019), non-high-density lipoprotein cholesterol (non-HDL-C) (β= − 0.149,p= 0.001), and TG/HDL-C ratio, a marker of the LDL particle size (β= − 0.104,p= 0.02), while not being correlated with any other lipid parameters. On the other hand, while the ∆ docosahexaenoic acid (DHA)/AA ratio was inversely correlated with the changes of the serum HDL-C level and positively correlated with the changes of the TG/HDL-C ratio, possibly serving to promote development of atherosclerosis. The results suggest that an increase of the EPA/AA ratio might be associated with decrease of the serum levels of LDL-C, TG and non-HDL-C levels, as well as with an increase of the TG/HDL-C ratio, which represents increased LDL particle size, all of which play a role in the development of ASCVD. A high EPA/AA ratio, but not DHA/AA ratio, derived from fish consumption might reduce the risk of ASCVD through reducing the risk of development of atherosclerosis.Clinical Trial Registration Information: UMIN ( http://www.umin.ac.jp/ ), Study ID: UMIN000010603.