Platinum Group Metal Compounds in Cancer Chemotherapy An overview of the history and the potential of anticancer pgm compounds
Platinum Group Metal Compounds in Cancer Chemotherapy An overview of the history and the potential of anticancer pgm compounds
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DOI：
10.1595/205651317x693624
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发表时间：
2017-01-01
影响因子：
2.3
通讯作者：
Barnard, Christopher
中科院分区：
文献类型：
--
作者：
Barnard, Christopher
大约50年前，巴内特罗森伯格和同事发表了他们关于细菌生长的不寻常模式的研究，这些研究导致铂化合物被鉴定为对抗某些癌症，特别是泌尿生殖系统癌症的高效药物。这引发了世界各地对金属化合物作为小分子治疗剂的潜力的新兴趣。其中一些历史，特别是与铂族金属（pgm）铂和钌有关的历史，将在本综述中描述。
It was some 50 years ago that Barnett Rosenberg and coworkers published their studies on unusual patterns of bacterial growth that led to the identification of platinum compounds as highly effective agents against some cancers, particularly those of genitourinary origin. This sparked a renewed interest around the world in the potential of metal compounds as small molecule therapeutic agents. Some of that history, particularly related to the platinum group metals (pgm) platinum and ruthenium, is described in this overview.