SEMISYNTHETIC APPROACHES TO NOVEL PENICILLINS .2.
SEMISYNTHETIC APPROACHES TO NOVEL PENICILLINS .2.
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DOI：
10.1016/0968-0004(91)90092-a
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发表时间：
1991-06-01
影响因子：
13.8
通讯作者：
NAYLER, JHC
中科院分区：
文献类型：
--
作者：
NAYLER, JHC
这篇关于青霉素发现的文章的第一部分发表在上个月的TIBS上，最后发现了6-β-氨基青霉烷酸（6-阿帕），这是青霉素结构的核心。 6-阿帕的开发导致了一系列临床上重要的半合成青霉素的制备，这在本文中进行了描述。
The first part of this account of the discovery of penicillin, published in last month's issue of TIBS, concluded with the detection of 6-beta-amino-penicillanic acid (6-APA), the nucleus of the penicillin structure. The exploitation of 6-APA led to the preparation of a range of clinically important semi-synthetic penicillins, which is described in this article.