NEURITIC GROWTH MAINTAINED NEAR THE LESION SITE LONG AFTER SPINAL-CORD TRANSECTION IN THE NEWBORN RAT
NEURITIC GROWTH MAINTAINED NEAR THE LESION SITE LONG AFTER SPINAL-CORD TRANSECTION IN THE NEWBORN RAT
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DOI：
10.1016/0304-3940(81)90425-0
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
STELZNER, DJ
中科院分区：
文献类型：
--
作者：
BERNSTEIN, DR;BECHARD, DE;STELZNER, DJ
将新生和断奶大鼠的脊髓在胸中部横断。3或6个月。然后用电镜观察病灶边缘。两组均未发现损伤部位轴突再生的迹象，即使新生儿手术中胶质反应最小。在两组手术中，在病变部位两侧的反应区均发现反应性轴突末梢（推测为原始手术所致）和神经炎生长。在两组手术中，轴突生长（再生或生成）的潜力显然保持在病变的边缘。
The spinal cord of neonatal and weanling rats was mid-thoracically transected. Either 3 or 6 mo. later the borders of the lesion site were studied by EM. No sign of axonal regeneration through the lesion site was found in either group, even though the glial reaction was minimal in neonatal operates. In both groups of operates, reactive axonal endings, presumed to result from the original surgery and neuritic growth were found in a reactive zone on both sides of the lesion site. Potential for axonal growth (regeneration or generation) is apparently maintained at the borders of the lesion in both groups of operates.