The Cellular and Molecular Landscapes of the Developing Human Central Nervous System.
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System.
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DOI：
10.1016/j.neuron.2015.12.008
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发表时间：
2016-01-20
期刊：
影响因子：
16.2
通讯作者：
Sestan N
中科院分区：
文献类型：
--
作者：
Silbereis JC;Pochareddy S;Zhu Y;Li M;Sestan N
人类中枢神经系统遵循所有哺乳动物的典型发育模式，但某些神经发育特征高度衍生。构建人类中枢神经系统需要在很长一段时间内对大量细胞类型中的无数分子和细胞过程进行精确的编排和协调。这些过程的失调会影响CNS的结构和功能，并可能导致神经或精神疾病。最近的技术进步和对人类神经发育的日益关注使得人类CNS及其在健康和疾病中的发育能够得到更全面的表征。本综述的目的是强调最近的进展，我们了解的分子和细胞景观的发展中的人类中枢神经系统，重点是大脑新皮层，这些发现提供了人类神经进化，功能和功能障碍的见解。
The human central nervous system follows a pattern of development typical of all mammals, but certain neurodevelopmental features are highly derived. Building the human CNS requires the precise orchestration and coordination of myriad molecular and cellular processes across a staggering array of cell types and over a long period of time. Dysregulation of these processes affects the structure and function of the CNS and can lead to neurological or psychiatric disorders. Recent technological advances and increased focus on human neurodevelopment have enabled a more comprehensive characterization of the human CNS and its development in both health and disease. The aim of this review is to highlight recent advancements in our understanding of the molecular and cellular landscapes of the developing human CNS, with focus on the cerebral neocortex, and the insights these findings provide into human neural evolution, function, and dysfunction.