Membrane recruitment of effector proteins by Arf and Rab GTPases
Membrane recruitment of effector proteins by Arf and Rab GTPases
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DOI：
10.1016/j.sbi.2005.10.015
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发表时间：
2005-12-01
影响因子：
6.8
通讯作者：
Wakatsuki, S
中科院分区：
文献类型：
--
作者：
Kawasaki, M;Nakayama, K;Wakatsuki, S
在其GTP结合形式中，Arf和Rab家族GTP酶与不同的细胞器膜相关联，它们向细胞器膜募集调节囊泡运输的特定效应蛋白。Arf GTP酶通过募集外壳蛋白参与包被载体囊泡的形成。另一方面，Rab GTP酶参与运输囊泡与靶细胞器的拴系、对接和融合，与拴系和融合机制协同作用。Arf 1-GGA和Rab 5-Rabaptin-5复合物以及与Arf和Rab GTP酶复合的其他效应结构的最近结构研究揭示了这些效应蛋白的GTP依赖性膜募集的机制。
In their GTP-bound form, Arf and Rab family GTPases associate with distinct organelle membranes, to which they recruit specific sets of effector proteins that regulate vesicular transport. The Arf GTPases are involved in the formation of coated carrier vesicles by recruiting coat proteins. On the other hand, the Rab GTPases are involved in the tethering, docking and fusion of transport vesicles with target organelles, acting in concert with the tethering and fusion machineries. Recent structural studies of the Arf1-GGA and Rab5-Rabaptin-5 complexes, as well as other effector structures in complex with the Arf and Rab GTPases, have shed light on the mechanisms underlying the GTP-dependent membrane recruitment of these effector proteins.