A Solvent and Initiator Free, Low-Modulus, Degradable Polyester Platform with Modular Functionality for Ambient-Temperature 3D Printing
A Solvent and Initiator Free, Low-Modulus, Degradable Polyester Platform with Modular Functionality for Ambient-Temperature 3D Printing
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DOI：
10.1021/acs.macromol.5b02399
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发表时间：
2016-04-12
期刊：
影响因子：
5.5
通讯作者：
Joy, Abraham
中科院分区：
文献类型：
--
作者：
Govindarajan, Sudhanva R.;Xu, Ying;Joy, Abraham
3D 打印使生物材料能够设计成复杂的定制支架。然而，由于残留单体、自由基引发剂、溶剂或在高温下打印，目前的 3D 打印生物材料支架存在潜在的缺点。这项工作描述了一种用于室温 3D 打印的溶剂、引发剂和无单体可降解聚酯平台。源自大豆油的亚油酸侧链可降低 T-g，防止堆积和缠结，确保室温打印时 G '' > G'。打印后，侧链功能化香豆素部分的交联将粘性细丝固定到弹性体固体上。此外，聚酯平台的模块化设计能够实现配体的缀合，正如 FITC 与 3D 打印支架上表面胺的缀合所证明的那样。这种低模量、可打印的聚酯平台解决了功能性生物材料 3D 打印中的几个设计挑战，并且可能在许多组织工程应用中发挥作用。
3D printing has enabled the design of biomaterials into intricate and customized scaffolds. However, current 3D printed biomaterial scaffolds have potential drawbacks due to residual monomers, free-radical initiators, solvents, or printing at elevated temperatures. This work describes a solvent, initiator, and monomer-free degradable polyester platform for room temperature 3D printing. Linoleic acid side chains derived from soybean oil lowers the T-g and prevents packing and entanglement, ensuring that G '' > G' during room temperature printing. Upon printing, cross-linking of pendant functionalized coumarin moieties fixes the-viscous filaments to elastomeric solids. Furthermore, the modular design of the polyester platform enables conjugation of ligands, as demonstrated by the conjugation of FITC to surface amines on the 3D printed scaffolds. This low modulus, printable polyester platform addresses several design challenges in 3D printing of functional biomaterials and could potentially be useful in many tissue engineering applications.