Tramadol for postoperative shivering: A double-blind comparison with pethidine
Tramadol for postoperative shivering: A double-blind comparison with pethidine
复制标题
DOI：
10.1177/0310057x0102900209
复制
发表时间：
2001-04-01
影响因子：
1.5
通讯作者：
Mishra, S
中科院分区：
文献类型：
--
作者：
Bhatnagar, S;Saxena, A;Mishra, S
在大多数手术室和恢复室中，通过使用加湿器、保暖毯和吸入加湿加热氧气来控制颤抖。然而，药物控制是一种有效的替代治疗方式。这项随机、双盲试验在 30 名 ASA 1 级或 2 级患者中进行，旨在探讨曲马多和哌替啶治疗麻醉后颤抖的疗效，曲马多是脊髓中血清素（5-羟色胺）和去甲肾上腺素再摄取的抑制剂。这有利于 5-羟色胺的释放，从而影响体温调节控制。我们比较了曲马多和哌替啶的疗效，哌替啶是目前广泛使用的控制颤抖的药物。患者静脉注射曲马多1 mg/kg或哌替啶0.5 mg/kg，注射后每10分钟观察颤抖程度、脉率、血压和呼吸频率，持续1小时。曲马多组停止颤抖的可能性明显更大（15 例中的 12 例对 15 例中的 4 例）。P
In most operating and recovery rooms, shivering is controlled by the use of humidifiers, warming blankets, and inhalation of humidified heated oxygen. However, pharmacological control is an effective alternate treatment modality. This randomized, double-blind trial conducted in 30 ASA Grade 1 or 2 patients, was designed to explore the efficacy of tramadol and pethidine in the treatment of post-anaesthetic shivering,Tramadol is an inhibitor of the re-uptake of serotonin (5-hydroxyptamine) and norepinephrine in the spinal cord. This facilitates 5-hydroxytryptamine release, which influences thermoregulatory control. We compared the efficacy of tramadol with that of pethidine, presently a widely used drug for the control of shivering. Patients received either tramadol 1 mg/kg or pethidine 0.5 mg/kg intravenously and the grade of shivering, pulse rate, blood pressure and respiratory rate were observed every 10 minutes after injection for one hour. Shivering was significantly more likely to have ceased in the tramadol group (12 of 15 versus 4 of 15 cases. P