Immune Checkpoint-Mediated Interactions Between Cancer and Immune Cells in Prostate Adenocarcinoma and Melanoma.
Immune Checkpoint-Mediated Interactions Between Cancer and Immune Cells in Prostate Adenocarcinoma and Melanoma.
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DOI：
10.3389/fimmu.2018.01786
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发表时间：
2018
影响因子：
7.3
通讯作者：
Bellone M
中科院分区：
文献类型：
--
作者：
Elia AR;Caputo S;Bellone M
前列腺腺癌 (PCa) 和黑色素瘤是肿瘤的典型例子，它们对基于针对 T 淋巴细胞调节途径的单克隆抗体的疗法（即免疫检查点阻断 (ICB)）敏感性较差或高度敏感。然而，大约 40% 的黑色素瘤患者对 ICB 具有耐药性或获得耐药性。 PCa 和 ICB 耐药性黑色素瘤微环境的特征分别是细胞毒性 T 细胞浸润不足和强烈的免疫抑制。在这里，我们比较了这两个癌症患者亚组的肿瘤微环境，重点关注一些最具代表性的免疫检查点分子：细胞毒性 T 淋巴细胞相关抗原 4、程序性死亡 1、淋巴细胞激活基因 3 以及 T 细胞免疫球蛋白和粘蛋白域含有 3。我们还报告了几个由抑制性免疫检查点介导的癌症和免疫细胞之间串扰的例子，并确定了旨在克服 PCa 和黑色素瘤中 ICB 耐药性的有前途的策略。
Prostate adenocarcinoma (PCa) and melanoma are paradigmatic examples of tumors that are either poorly or highly sensitive to therapies based on monoclonal antibodies directed against regulatory pathways in T lymphocytes [i.e., immune checkpoint blockade (ICB)]. Yet, approximately 40% of melanoma patients are resistant or acquire resistance to ICB. What characterize the microenvironment of PCa and ICB-resistant melanoma are a scanty cytotoxic T cell infiltrate and a strong immune suppression, respectively. Here, we compare the tumor microenvironment in these two subgroups of cancer patients, focusing on some among the most represented immune checkpoint molecules: cytotoxic T lymphocyte-associated antigen-4, programmed death-1, lymphocyte activation gene-3, and T cell immunoglobulin and mucin-domain containing-3. We also report on several examples of crosstalk between cancer and immune cells that are mediated by inhibitory immune checkpoints and identify promising strategies aimed at overcoming ICB resistance both in PCa and melanoma.
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影响因子：
82.9
作者：
Gao J;Ward JF;Pettaway CA;Shi LZ;Subudhi SK;Vence LM;Zhao H;Chen J;Chen H;Efstathiou E;Troncoso P;Allison JP;Logothetis CJ;Wistuba II;Sepulveda MA;Sun J;Wargo J;Blando J;Sharma P
通讯作者：
Sharma P
影响因子：
30.5
作者：
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通讯作者：
Jinushi, Masahisa
影响因子：
15.9
作者：
Baitsch, Lukas;Baumgaertner, Petra;Speiser, Daniel E.
通讯作者：
Speiser, Daniel E.
从头表观遗传程序抑制PD-1封锁介导的T细胞再生。
影响因子：
64.5
作者：
Ghoneim HE;Fan Y;Moustaki A;Abdelsamed HA;Dash P;Dogra P;Carter R;Awad W;Neale G;Thomas PG;Youngblood B
通讯作者：
Youngblood B
影响因子：
4.7
作者：
Bellone M;Calcinotto A
通讯作者：
Calcinotto A