Alteration of the blood-retinal barrier in experimental diabetes mellitus.
Alteration of the blood-retinal barrier in experimental diabetes mellitus.
复制标题
实验性糖尿病中血视网膜屏障的改变。
DOI：
10.1001/archopht.1978.03910050480018
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发表时间：
1978
影响因子：
--
通讯作者：
B. Becker
中科院分区：
文献类型：
--
作者：
S. Waltman;T. Krupin;S. Hanish;C. Oestrich;B. Becker
玻璃体荧光光度法用于评价戴帽大鼠血-视网膜屏障对荧光素的完整性。链脲佐菌素诱发的糖尿病在10天内就破坏了这一屏障。用胰岛素使血糖水平正常化显著降低（P <0.005）增加的渗透性。这种功能性微血管病变可能被证明是实验性糖尿病视网膜循环中最早可检测到的变化。
Vitreous fluorophotometry was used to evaluate the integrity of the blood-retinal barrier to fluorescein in hooded rats. Streptozotocin-induced diabetes mellitus caused a breakdown of this barrier within ten days. Normalization of blood glucose levels with insulin significantly reduced (P less than .005) the increased permeability. This functional microangiopathy might prove to be the earliest detectable change in the retinal circulation in experimental diabetes.