Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH).
Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH).
复制标题
DOI：
10.1136/bmjopen-2022-069427
复制
发表时间：
2023-10-04
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
抑郁和焦虑困扰着全世界数百万人，造成相当大的残疾。MULTI-PSYCH是一个纵向队列的基因型和表型的个人抑郁症或焦虑症谁经历了高度结构化的基于互联网的认知行为治疗（ICBT）。MULTI-PSYCH的首要目的是改善风险分层、结果预测和二级预防干预。MULTI-PSYCH是一项精准医学计划，结合了临床，遗传和全国注册数据。MULTI-PSYCH包括2668名临床特征良好的成年人，患有重度抑郁症（MDD）（n=1300）、社交焦虑症（n=640）或惊恐障碍（n=728），在瑞典斯德哥尔摩的互联网精神病学诊所接受ICBT治疗前、治疗期间和治疗后进行评估。所有患者均进行了血液采样和基因分型。临床和遗传数据已与瑞典的几个登记册相联系，其中载有从病人出生到ICBT结束后10年的各种变量。这些变量类型包括围产期并发症，学校成绩，精神和躯体并发症，分发药物，医疗干预和诊断，医疗保健和社会福利，人口统计学，收入等。长期随访数据将收集到2029年。MULTI-PSYCH的最初用途包括发现自闭症谱系障碍的PRS与对ICBT的反应之间的关联，开发用于MDD中ICBT后缓解状态基线预测的机器学习模型，以及对ICBT结果的全基因组关联研究的数据贡献。其他项目已经启动或正在规划阶段。MULTI-PSYCH队列提供了一个独特的基础设施，不仅可以研究预测因素或短期治疗结果，还可以研究接受ICBT治疗抑郁或焦虑患者的长期医疗和社会经济结果。MULTI-PSYCH为研究合作做好了充分的准备。
Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped and phenotyped individuals with depression or anxiety disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The overarching purpose of MULTI-PSYCH is to improve risk stratification, outcome prediction and secondary preventive interventions. MULTI-PSYCH is a precision medicine initiative that combines clinical, genetic and nationwide register data. MULTI-PSYCH includes 2668 clinically well-characterised adults with major depressive disorder (MDD) (n=1300), social anxiety disorder (n=640) or panic disorder (n=728) assessed before, during and after 12 weeks of ICBT at the internet psychiatry clinic in Stockholm, Sweden. All patients have been blood sampled and genotyped. Clinical and genetic data have been linked to several Swedish registers containing a wide range of variables from patient birth up to 10 years after the end of ICBT. These variable types include perinatal complications, school grades, psychiatric and somatic comorbidity, dispensed medications, medical interventions and diagnoses, healthcare and social benefits, demographics, income and more. Long-term follow-up data will be collected through 2029. Initial uses of MULTI-PSYCH include the discovery of an association between PRS for autism spectrum disorder and response to ICBT, the development of a machine learning model for baseline prediction of remission status after ICBT in MDD and data contributions to genome wide association studies for ICBT outcome. Other projects have been launched or are in the planning phase. The MULTI-PSYCH cohort provides a unique infrastructure to study not only predictors or short-term treatment outcomes, but also longer term medical and socioeconomic outcomes in patients treated with ICBT for depression or anxiety. MULTI-PSYCH is well positioned for research collaboration.
登录
查看更多内容
影响因子：
6.2
作者：
Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium
通讯作者：
Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium
影响因子：
10.3
作者：
Edmonds, M.;Hadjistavropoulos, H. D.;Titov, N.
通讯作者：
Titov, N.
影响因子：
6.9
作者：
Fresco, DM;Coles, ME;Goetz, D
通讯作者：
Goetz, D
影响因子：
4.4
作者：
Bergstrom, Jan;Andersson, Gerhard;Lindefors, Nils
通讯作者：
Lindefors, Nils
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.