Targets for cancer therapy in the cell cycle pathway.
Targets for cancer therapy in the cell cycle pathway.
复制标题
DOI：
10.1097/00001622-199611000-00012
复制
发表时间：
1996-11
影响因子：
3.4
通讯作者：
R. Rao
中科院分区：
文献类型：
--
作者：
R. Rao
细胞周期的进展是一个复杂的过程，在许多水平上受到几种蛋白质的调节。我们刚刚开始了解这些蛋白质是如何完成这种调节的。p16-cyclin D1.cdk4-pRb通路是最重要的通路之一，其在大多数不同类型的癌症中改变。本文综述了这一通路中的一些蛋白质，这些蛋白质为药物发现提供了新的机会。一些准则，以评估这些蛋白质的相关性作为癌症治疗的目标和开发一个针对多个途径的联合治疗的重要性进行了讨论。
Progression through the cell cycle is a complex process that is regulated at many levels by several proteins. We are just beginning to understand how these proteins accomplish this regulation. The p16-cyclin D1.cdk4-pRb pathway is one of the most important pathways, which is altered in a majority of cancers of different types. This review focuses on some of the proteins in this pathway that offer new opportunities for drug discovery. Some guidelines to evaluate the relevance of these proteins as targets for cancer therapy and the importance of developing a combination therapy targeting multiple pathways are also discussed.