Mathematical description of gene regulatory units
Mathematical description of gene regulatory units
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DOI：
10.1529/biophysj.106.081828
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发表时间：
2006-08-15
影响因子：
3.4
通讯作者：
Kimura, Hidenori
中科院分区：
文献类型：
--
作者：
Tanaka, Reiko J.;Okano, Hiroyuki;Kimura, Hidenori
揭示负责细胞令人惊讶地组织良好的功能的控制机制应该直接导致对细胞如何适应异常变化的环境的更好的理解。一个系统地描述各种生化调控功能的模型的一般框架不仅有助于系统地解释为某些系统提出的各种模型，而且有助于进一步理解不同生物系统背后的一般控制机制和设计原则。本文提出了一个描述基因调控单位的统一数学框架。该框架与经典控制理论框架具有较好的兼容性，可以作为工程控制理论与生物防治机理之间的桥梁。它还应提供不同监管单位的统一观点，并促进对各种文献中提出的不同数学模型进行系统比较。
Revealing the control mechanisms responsible for the cell's surprisingly well-organized functions should lead directly to a better understanding of how the cell adapts to extraordinarily changing environments. A general framework for describing models that can represent diverse biochemical regulatory functions systematically would help not only systematic interpretation of the various models proposed for certain systems but also further understanding of the general control mechanism and design principles underlying different biological systems. This article presents a unified mathematical framework for describing gene regulatory units. The proposed framework is fairly compatible with the classical control theoretical framework, so it should serve as a connecting bridge between engineering control theory and biological control mechanisms. It should also provide a unified view of different regulatory units and facilitate systematic comparison of different mathematical models proposed in a variety of literature.