Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study
Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study
复制标题
DOI：
10.1016/j.vaccine.2015.10.100
复制
发表时间：
2016-01-02
期刊：
影响因子：
5.5
通讯作者：
Leuridan, Elke
中科院分区：
文献类型：
--
作者：
Maertens, Kirsten;Cabore, Raissa Nadege;Leuridan, Elke
一些国家建议在怀孕期间接种疫苗，作为保护幼儿免受严重感染的一种手段。然而，许多方面仍然未知，母体抗体可能会削弱婴儿的免疫反应，这是母体疫苗接种的担忧之一。我们报告了第一项针对妇女和婴儿的前瞻性对照队列研究，研究怀孕期间使用 Boostrix（一种破伤风、白喉和无细胞百日咳联合疫苗）的效果。主要目的是测量该加强剂量对婴儿体内母体抗体的滴度和持续时间的影响，并评估对婴儿免疫反应的可能干扰。在一项对照队列研究中，57 名孕妇在平均孕龄为 28.6 周时接种了 Tdap 疫苗（破伤风白喉无细胞百日咳、Boostrix、GSK Biologicals）。对照组孕妇 (N = 42) 未接种疫苗。通过商业 ELISA 测试，在母亲接种疫苗前和接种后一个月、分娩时和脐带血以及婴儿接种前和接种后 1 个月采集的样本中，测量破伤风 (TT)、白喉 (DT)、百日咳毒素 (PT)、丝状血凝素 (FHA) 和百日咳毒素 (Pm) 的抗体几何平均浓度 (GMC) 3 种含有六价百日咳疫苗的疫苗。与未接种疫苗的女性的后代相比，接种疫苗的女性所生的婴儿在出生时和出生后头 2 个月内所有疫苗抗原的 GMC 均显着较高，从而缩小了婴儿对百日咳的易感性差距。然而，注意到婴儿白喉和百日咳毒素疫苗反应减弱（p
Vaccination during pregnancy has been recommended in some countries as a means to protect young infants from severe infection. Nevertheless, many aspects are still unknown and possible blunting of the infant's immune responses by maternal antibodies, is one of the concerns with maternal vaccination. We report the first prospective controlled cohort study in women and infants on the effects of using Boostrix, a combined tetanus, diphtheria and acellular pertussis vaccine, during pregnancy. The primary aim was to measure the influence of this booster dose on the titer and duration of the presence of maternal antibodies in the infants and assess possible interference with infant immune responses.In a controlled cohort study, 57 pregnant women were vaccinated with Tdap vaccine (Tetanus Diphtheria acellular Pertussis, Boostrix, GSK Biologicals), at a mean gestational age of 28.6 weeks. A control group of pregnant women (N= 42) received no vaccine. Antibody geometric mean concentrations (GMCs) against tetanus (TT), diphtheria (DT), pertussis toxin (PT), filamentous haemagglutinin (FHA) and pertactin (Pm) were measured with commercial ELISA tests in samples taken preceding maternal vaccination and one month afterwards, at delivery and from the cord blood, and in infants before and 1 month after the primary series of 3 pertussis containing hexavalent vaccines.Infants born to vaccinated women had significantly higher GMC at birth and during the first 2 months of life for all vaccine antigens compared to the offspring of unvaccinated women, thereby closing the susceptibility gap for pertussis in infants. However, blunting was noticed for infant diphtheria and pertussis toxin vaccine responses (p