Affective and non-affective touch evoke differential brain responses in 2-month-old infants
Affective and non-affective touch evoke differential brain responses in 2-month-old infants
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DOI：
10.1016/j.neuroimage.2017.12.024
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发表时间：
2018-04-01
期刊：
影响因子：
5.7
通讯作者：
Nissila, Ilkka
中科院分区：
文献类型：
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作者：
Jonsson, Emma H.;Kotilahti, Kalle;Nissila, Ilkka
爱抚是一种有效的方式来交流情感和创造社会纽带。它也是早期父母结合的关键介质之一。爱抚通常被认为是一种社会形式的触摸，事实上，缓慢，温柔的刷牙是编码在专门的外周神经纤维，C-触觉（CT）传入。在成年人中，诸如后颞沟和上级颞沟的区域被情感性的、缓慢的抚摸刺激激活，而不是被快速的抚摸刺激激活。然而，这些地区是否被激活的婴儿，社会触觉stimulation.In这项研究中，我们比较了总血红蛋白反应测量与扩散光学断层扫描（DOT）在左半球缓慢和快速抚摸触摸刺激16个2个月大的婴儿。我们比较了慢速划动（最佳CT传入刺激）和快速划动（非最佳CT刺激）。使用两种方法描绘激活区域：一种基于两种条件之间的对比，另一种基于两种条件之间差异的基于体素的统计显著性。第一种方法显示了颞叶皮层中的单个激活簇，其重心位于颞中回，其中相对于快速划动，缓慢划动后总血红蛋白增加（p = 0.04，未校正）。第二种方法显示，相对于快速划动，慢速划动导致岛叶皮质中总血红蛋白增加（未校正p = 0.0005;多重比较校正p = 0.04），这些激活簇包括成人大脑中涉及情感性慢速划动触摸处理的区域。我们的结论是，婴儿的大脑显示出明显的和成人一样的反应，以缓慢的抚摸触摸相比，快速抚摸触摸岛叶皮层，但预期的反应在初级体感皮层没有发现在这个年龄。结果表明，情感价触摸在出生后不久就以成人的方式在大脑中编码，这表明触摸可能参与与看护人的联系。
Caressing touch is an effective way to communicate emotions and to create social bonds. It is also one of the key mediators of early parental bonding. The caresses are generally thought to represent a social form of touching and indeed, slow, gentle brushing is encoded in specialized peripheral nerve fibers, the C-tactile (CT) afferents. In adults, areas such as the posterior insula and superior temporal sulcus are activated by affective, slow stroking touch but not by fast stroking stimulation. However, whether these areas are activated in infants, after social tactile stimulation, is unknown.In this study, we compared the total hemoglobin responses measured with diffuse optical tomography (DOT) in the left hemisphere following slow and fast stroking touch stimulation in 16 2-month-old infants. We compared slow stroking (optimal CT afferent stimulation) to fast stroking (non-optimal CT stimulation). Activated regions were delineated using two methods: one based on contrast between the two conditions, and the other based on voxel-based statistical significance of the difference between the two conditions. The first method showed a single activation cluster in the temporal cortex with center of gravity in the middle temporal gyrus where the total hemoglobin increased after the slow stroking relative to the fast stroking (p = 0.04 uncorrected). The second method revealed a cluster in the insula with an increase in total hemoglobin in the insular cortex in response to slow stroking relative to fast stroking (p = 0.0005 uncorrected; p = 0.04 corrected for multiple comparisons).These activation clusters encompass areas that are involved in processing of affective, slow stroking touch in the adult brain. We conclude that the infant brain shows a pronounced and adult-like response to slow stroking touch compared to fast stroking touch in the insular cortex but the expected response in the primary somatosensory cortex was not found at this age. The results imply that emotionally valent touch is encoded in the brain in adult-like manner already soon after birth and this suggests a potential for involvement of touch in bonding with the caretaker.