The potential use of saliva to detect recurrence of disease in women with breast carcinoma
The potential use of saliva to detect recurrence of disease in women with breast carcinoma
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DOI：
10.1034/j.1600-0714.2002.00123.x
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发表时间：
2002-08-01
影响因子：
3.3
通讯作者：
Bigler, SA
中科院分区：
文献类型：
--
作者：
Bigler, LR;Streckfus, CF;Bigler, SA
背景：大约每10名女性中就有1人在其一生中会患乳腺癌。研究表明，乳腺癌筛查可降低乳腺癌死亡率。基于唾液的检测在乳腺癌患者的术后和/或辅助治疗管理中可能非常有用。
方法：进行了以下研究，以确定癌基因c - erbB - 2的唾液蛋白产物在跟踪诊断为乳腺癌的患者方面可能的有用性。本研究纳入了25名平均年龄为54岁的患者，她们具有不同的乳腺癌组织学诊断结果和分期。在所有患者接受任何辅助治疗或手术之前以及治疗过程中依次采集血清和刺激后的全唾液样本，对c - erbB - 2和CA 15 - 3进行酶联免疫吸附测定（ELISA）。
结果：以标志物浓度为因变量，治疗方案和系列评估为自变量进行的广义线性模型（GLM）分析结果显示，血清的整体模型具有显著性（P
Background: Approximately 1 woman in every 10 will develop breast cancer in her lifetime. It has been shown that screening for breast cancer can reduce breast cancer mortality. The use of a saliva-based test could prove to be very useful in post-operative and/or adjunctive therapy management of breast cancer patients.Methods: The following study was undertaken to establish the possible usefulness of the salivary protein product of the oncogene c-erbB-2 in following patients diagnosed with carcinoma of the breast. Included in this study were 25 patients with a mean age of 54 years with varying histological diagnoses and stages of carcinoma of the breast. ELISA assays for c-erb B-2 and CA 15-3 were performed on serum and stimulated whole saliva samples collected on all patients prior to any adjunct therapy or surgery and sequentially during therapy.Results: The results of the GLM analyses using marker concentration as the dependent variable and treatment regimen and the serial assessments as independent variables yielded a significant overall model for both the serum (P