Brain donation in normal aging: Procedures, motivations, and donor characteristics from the biologically resilient adults in neurological studies (BRAiNS) project
Brain donation in normal aging: Procedures, motivations, and donor characteristics from the biologically resilient adults in neurological studies (BRAiNS) project
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DOI：
10.1093/geront/41.6.716
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发表时间：
2001-12-01
期刊：
影响因子：
5.7
通讯作者：
Markesbery, WR
中科院分区：
文献类型：
--
作者：
Schmitt, FA;Wetherby, MMC;Markesbery, WR
在过去的几十年里，医疗尸检率一直在下降，然而，十多年来，肯塔基大学阿尔茨海默病研究中心一直在招募健康的老年人加入一个项目，该项目包括每年一次的精神状况评估、一年两次的医学和神经检查，以及预先安排的尸检。本文侧重于这些捐赠者的特点，以探讨有助于作出捐赠决定的潜在因素。这一独特群体的动机可以帮助医生为医疗和研究目的要求尸检。参加这项计划的500多名志愿者是60岁以上受过良好教育的社区成年人。他们的动机通常是阿尔茨海默氏症的个人经历，已经登记的人的推荐，以及促进科学知识的愿望。这些志愿者的理由表明，通过向个人和家庭提供有关该程序的医疗和科学价值的信息，可以提高用于基础研究和死因调查的组织捐赠或尸检的比率。在研究环境中，鼓励参与者招募朋友或家人可能会提高组织获得率。
Medical autopsy rates have been declining for the past several decades, yet, for more than a decade, the University of Kentucky Alzheimer's Disease Research Center has been recruiting healthy older adults into a program involving annual assessments of mental status, biannual medical and neurological exams, and prearranged postmortem brain examination. The present article focuses on the characteristics of these donors to explore potential factors that contribute to the decision to donate. The motivations of this unique group of individuals could serve to inform physicians who request autopsies for medical and research purposes. Over 500 volunteers who have enrolled in this program are well-educated community-dwelling adults over the age of 60. They are generally motivated by personal experiences with Alzheimer's disease, referral by someone already enrolled, and a desire to promote scientific knowledge. These volunteers' reasons suggest that rates of tissue donation or autopsy for basic research and investigations of causes of death might be increased by providing individuals and families with information concerning the medical and scientific value of the procedure. Within research settings, encouraging participant recruitment of friends or family members would likely increase tissue acquisition rates.