Muscle-specific protein MDP77 specifically promotes motor nerve regeneration in rats
Muscle-specific protein MDP77 specifically promotes motor nerve regeneration in rats
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DOI：
10.1016/j.neulet.2004.02.058
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发表时间：
2004-04-29
影响因子：
2.5
通讯作者：
Taguchi, T
中科院分区：
文献类型：
--
作者：
Itoh, S;Uyeda, A;Taguchi, T
本研究观察了重组人MDP77(RhMDP77)对坐骨神经再生的影响。我们进行了桥接(14 Mm)：在SD-Dawley大鼠的坐骨神经内，使用含有I型胶原和0、5、10或20mug/mlrhMDP77的混合物的硅胶管，或含有磷酸盐缓冲液的硅胶管(每组6只)。植入12周后进行的电生理和组织学评估表明，rhMDP77对再生神经的末梢和侧枝萌发有积极的作用，从而以剂量依赖的方式促进运动神经的再生。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
This study has examined the effects of recombinant human MDP77 (rhMDP77) on sciatic motor nerve regeneration in vivo. We carried out bridge grafting (14 mm):into the sciatic nerve of Sprague-Dawley rat, using silicone tubes containing a mixture of type-I collagen and 0, 5, 10, or 20 mug/ml of rhMDP77, or containing phosphate-buffered solution (N = 6 in each group). Electrophysiological and histological evaluations carried out 12 weeks after implantation suggest that rhMDP77 has a positive effect on terminal and collateral sprouting of regenerating nerves and thereby promotes motor nerve regeneration in a dose-dependent manner. (C) 2004 Elsevier Ireland Ltd. All rights reserved.