Regeneration of Aged Vocal Fold: First Human Case Treated With Fibroblast Growth Factor
Regeneration of Aged Vocal Fold: First Human Case Treated With Fibroblast Growth Factor
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DOI：
10.1097/mlg.0b013e3181845720
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发表时间：
2008-12-01
期刊：
影响因子：
2.6
通讯作者：
Ito, Juichi
中科院分区：
文献类型：
--
作者：
Hirano, Shigeru;Kishimoto, Yo;Ito, Juichi
背景/目的：老年声带的特点是萎缩的粘膜，这会导致发音困难，是难以治疗的。我们已经发现了治疗潜力的碱性成纤维细胞生长因子（bFGF）的组织再生的老年声带。我们在这里报告的第一个人的情况下，已被治疗bfGF.Study Design：机构审查委员会批准的临床human trial.Methods：一个63岁的男子声带萎缩进行了治疗局部注射10微克的碱性成纤维细胞生长因子进入左声带表面麻醉。结果：注射后1周，声带萎缩明显改善，声门间隙消失。空气动力学和声学参数也有显着改善。这些积极的影响保持了3 month.Conclusion：第一例老年声带治疗bFGF管理。结果是令人鼓舞的，表明对人类声带萎缩的治疗效果。
Background/Objectives: Aged vocal folds are characterized by atrophy of the mucosa, which causes dysphonia and is difficult to treat. We have revealed a therapeutic potential of basic fibroblast growth factor (bFGF) for tissue regeneration of the aged vocal fold. We report here the first human case that has been treated with bFGF.Study Design: Institutional review board approved clinical human trial.Methods: A 63-year-old man with atrophied vocal folds was treated by local injection of 10 mu g of bFGF into the left vocal fold under topical anesthesia. The effects of the injection were examined after 1 to 3 months by videostroboscopy, acoustic and aerodynamic measurements.Results: The atrophy of the vocal fold was improved at 1 week after the injection and glottic gap disappeared. Aerodynamic and acoustic parameters also showed remarkable improvement. These positive effects were maintained up to 3 months.Conclusion: The first case with aged vocal folds treated with bFGF administration is presented. The results are encouraging, suggesting therapeutic effects of for atrophied vocal folds in human.