Effects of chronic lead ingestion on social development in infant rhesus monkeys.
Effects of chronic lead ingestion on social development in infant rhesus monkeys.
复制标题
慢性铅摄入对幼年恒河猴社会发展的影响。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
Bowman Re
中科院分区：
文献类型：
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作者：
Bushnell Pj;Bowman Re
在四个独立的实验中，在各种铅（Pb）暴露条件下，研究了出生后一年内恒河猴幼猴的社会行为。每天摄入牛奶中的PB醋酸盐一年后，血液中的铅水平升高到30-100微克/分升，抑制了游戏，增加了社会依附，并加剧了观察年中期改变游戏环境所造成的社会行为破坏。社交测试组中对照猴的存在降低了铅诱导的社交行为变化的幅度。与出生后每日铅暴露相比，妊娠期慢性铅暴露对出生后社会发育没有可测量的影响，而急性、短暂的出生后铅暴露（在生命的第2个月期间产生血液铅水平> 200微克/分升）仅影响猴子对计划环境变化的反应。这些数据表明，每日摄入的铅，而不是以前获得的组织负担，负责观察到的社会发展的长期变化。结果进行了讨论，在灵长类动物的社会发展，这被认为是需要适当的社会融合和生殖行为在成熟的充分的互动发挥的一般情况下。
: The social behavior of infant rhesus monkeys during the first year of life was examined under a variety of lead (Pb) exposure conditions in four separate experiments. Daily ingestion of PB acetate in milk for one year elevated blood Pb levels to 30-100 microgram/dl, suppressed play, increased social clinging, and exacerbated the disruption of social behavior caused by changing the play environment midway through the year of observation. The presence of control monkeys in social test-groups reduced the magnitude of Pb-induced social behavior changes. In contrast to daily postnatal Pb exposure, chronic exposure to Pb during gestation had no measurable effect on postnatal social development, and acute, transient postnatal Pb exposure (producing blood Pb levels > 200 microgram/dl during month 2 of life) affected only the monkeys' response to the change in the plan environment. These data suggest that daily ingestion of Pb, and not a previously-acquired tissue burden, was responsible for the long-term changes in social development observed. The results are discussed in the general context of primate social development, which is thought to require adequate interactive play for appropriate social integration and reproductive behavior at maturity.