Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast
Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast
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DOI：
10.1126/science.290.5498.1975
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发表时间：
2000-12-08
期刊：
影响因子：
56.9
通讯作者：
Fujita, A
中科院分区：
文献类型：
--
作者：
Chen, T;Hiroko, T;Fujita, A
二倍体酵母细胞反复地从它们的两极分化和出芽，可能是因为未知成分的高度稳定的标记。在这里，Rax 2，一种膜蛋白，被证明表现为这样的标记。Rax 2蛋白本身在细胞皮层中遗传了多代，并且Rax 2的半衰期超过了几代。皮质蛋白质标记的持续遗传将提供一种将细胞的历史与精确形态发生形式的未来发展相结合的方法。
Diploid yeast cells repeatedly polarize and bud from their poles, probably because of highly stable marks of unknown composition. Here, Rax2, a membrane protein, was shown to behave as such a mark. The Rax2 protein itself was inherited immutably at the cell cortex for multiple generations, and Rax2 was shown to have a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means to couple a cell's history to the future development of a precise morphogenetic form.