Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors.
Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors.
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DOI：
10.1631/jzus.2005.b0033
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Wei, Er-qing
中科院分区：
文献类型：
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作者：
Hu, Hua;Yao, Hong-tian;Wei, Er-qing
目的：描述水通道蛋白（AQPs）之一的水通道蛋白 - 4（AQP4）在颅脑损伤或脑肿瘤患者的人脑标本中的表达情况。
方法：从颅脑损伤、脑肿瘤、良性脑膜瘤或早期出血性脑卒中患者获取19例人脑标本。采用磁共振成像（MRI）或计算机断层扫描（CT）评估脑水肿，苏木精 - 伊红染色评估细胞损伤，免疫组织化学法检测AQP4的表达。
结果：损伤后15小时至至少8天，AQP4表达增加。在星形细胞瘤、神经节胶质瘤和转移性腺癌周围，AQP4免疫反应性较强。然而，AQP4免疫反应性仅在星形细胞瘤和神经节胶质瘤的中心发现，在源自肺部的转移性腺癌中未发现。
结论：颅脑损伤后人脑、脑源性肿瘤内以及脑肿瘤周围的AQP4表达增加。
OBJECTIVE: To characterize the expression of aquaporin-4 (AQP4), one of the aquaporins (AQPs), in human brain specimens from patients with traumatic brain injury or brain tumors.METHODS: Nineteen human brain specimens were obtained from the patients with traumatic brain injury, brain tumors, benign meningioma or early stage hemorrhagic stroke. MRI or CT imaging was used to assess brain edema. Hematoxylin and eosin staining were used to evaluate cell damage. Immunohistochemistry was used to detect the AQP4 expression.RESULTS: AQP4 expression was increased from 15 h to at least 8 d after injury. AQP4 immunoreactivity was strong around astrocytomas, ganglioglioma and metastatic adenocarcinoma. However, AQP4 immunoreactivity was only found in the centers of astrocytomas and ganglioglioma, but not in metastatic adenocarcinoma derived from lung.CONCLUSION: AQP4 expression increases in human brains after traumatic brain injury, within brain-derived tumors, and around brain tumors.