Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements
Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements
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DOI：
10.1111/jne.12366
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发表时间：
2016-03
影响因子：
3.2
通讯作者：
F. V. Bussel;W. Backes;P. Hofman;M. Boxtel;M. Schram;Coen D. A. Stehouwer;J. Wildberger;J. Jansen
中科院分区：
文献类型：
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作者：
F. V. Bussel;W. Backes;P. Hofman;M. Boxtel;M. Schram;Coen D. A. Stehouwer;J. Wildberger;J. Jansen
2型糖尿病与认知功能减退有关。特别受影响的认知领域是学习和记忆，海马体在其中起着至关重要的作用。其病理生理机制仍有待进一步研究。本研究探讨了海马局部微结构和白色物质连接是否与2型糖尿病和记忆能力有关。40名2型糖尿病患者和38名非2型糖尿病患者接受了详细的认知评估和3特斯拉弥散磁共振成像（MRI）。进行扩散MRI以评估海马的微观结构（各向异性分数和平均扩散率）和白色物质连通性（束体积），并在患有和不患有2型糖尿病的参与者之间进行比较。海马微结构无差异。2型糖尿病患者海马和额叶之间的白色连接较少（P = 0.017）。无论是否患有2型糖尿病，记忆功能得分较低的参与者在海马和颞叶之间的白色连接较少（P = 0.017）。总之，2型糖尿病和记忆减退似乎与海马白色物质连接的改变有关。
Type 2 diabetes mellitus is associated with cognitive decrements. Specifically affected cognitive domains are learning and memory, for which the hippocampus plays an essential role. The pathophysiological mechanism remains to be revealed. The present study examined whether local hippocampal microstructure and white matter connectivity are related to type 2 diabetes and memory performance. Forty participants with type 2 diabetes and 38 participants without type 2 diabetes underwent detailed cognitive assessment and 3‐Tesla diffusion magnetic resonance imaging (MRI). Diffusion MRI was performed to assess microstructure (fractional anisotropy and mean diffusivity) and white matter connectivity (tract volume) of the hippocampus, which were compared between participants with and without type 2 diabetes. No differences in hippocampal microstructure were observed. Participants with type 2 diabetes had fewer white matter connections between the hippocampus and frontal lobe (P = 0.017). Participants who scored lower on memory function, regardless of type 2 diabetes, had fewer white matter connections between the hippocampus and temporal lobe (P = 0.017). Taken together, type 2 diabetes and memory decrements appear to be associated with altered hippocampal white matter connectivity.