VITAMIN-A DEFICIENCY AND NIGHT BLINDNESS
VITAMIN-A DEFICIENCY AND NIGHT BLINDNESS
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DOI：
10.1073/pnas.44.7.648
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发表时间：
1958-01-01
影响因子：
11.1
通讯作者：
WALD, G
中科院分区：
文献类型：
--
作者：
DOWLING, JE;WALD, G
这项研究绘制了大鼠维生素A缺乏症的整个过程及其治疗。在一组动物中，同时测量肝脏和血液中的维生素A、视紫红质和视蛋白的视网膜含量、视网膜电图阈值和在宽范围光强度下获得的ERG（视网膜电图）。在关键情况下，还检查了视网膜组织学。实验揭示了维生素A的可用性与某些身体变化之间的直接关系，指出了维生素在全身组织中的普遍和基本（但尚不清楚）功能。
This study maps the entire course of vitamin A deficiency and its cure in the rat. In single groups of animals, the vitamin A in the liver and blood, the retinal content of rhodopsin and opsin, the electroretinographic threshold, and the ERG''s (electroretinogram) obtained over a wide range of light intensities were measured simultaneously. In key instances the retinal histology were also examined. Experiments revealed a direct relationship between availability of vitamin A and certain body changes, pointing to a general and fundamental (but yet unknown) function of the vitamin in tissues all over the body.