Dietary intervention with oil rich fish reduces platelet-monocyte aggregation in man
Dietary intervention with oil rich fish reduces platelet-monocyte aggregation in man
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DOI：
10.1016/j.atherosclerosis.2007.04.047
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发表时间：
2008-03-01
期刊：
影响因子：
5.3
通讯作者：
Flapan, Andrew D.
中科院分区：
文献类型：
--
作者：
Din, Jehangir N.;Harding, Scott A.;Flapan, Andrew D.
背景：饮食中摄入富含omega-3脂肪酸的鱼类与心血管事件的减少有关。其机制尚不确定，并且之前研究对血小板功能影响的研究得出了不一致的结果。血小板-单核细胞聚集是血小板活化的敏感标志物，可能参与动脉粥样硬化血栓形成的发生和发展。本研究评估了饮食干预与油性鱼类对血小板-单核细胞聚集在healthy subjects.Methods：14名受试者的饮食补充500克的富含油的鱼，每周4周的影响。对照组14名受试者在4周内没有接受饮食干预。结果：鱼类饮食干预导致血浆磷脂中omega-3脂肪酸含量增加（14.2 +/-3.4%vs5.8 +/-1.3%，P < 0.001）。与对照组相比，用油性鱼进行饮食干预后，血小板-单核细胞聚集体减少了35%（16.0 +/- 9.0%对24.8 +/-10.9%，P < 0.01），并在停止补充4周后恢复到基础水平。血小板-单核细胞聚集率与血浆ω-3脂肪酸浓度呈负相关（r =-0.421，P = 0.006）。有血小板活化，可溶性P-选择素或可溶性CD 40 ligand.Conclusions的血浆标志物没有变化：我们已经证明，第一次，饮食干预与富含石油的鱼类减少血小板单核细胞aggregation. Our研究结果表明，减少血小板活化提供了一个潜在的机制，通过鱼油赋予其心血管预防的好处。(C)2007年由Elsevier爱尔兰有限公司出版。
Background: Dietary intake of fish rich in omega-3 fatty acids is associated with a reduction in cardiovascular events. The mechanisms for this are uncertain and previous studies investigating effects on platelet function have produced inconsistent results. Platelet-monocyte aggregation is a sensitive marker of platelet activation and may contribute to the initiation and progression of atherothrombosis. This study assessed the effect of dietary intervention with oily fish on platelet-monocyte aggregation in healthy subjects.Methods: Fourteen subjects had their diet supplemented with 500 g of oil-rich fish per week for 4 weeks. A control group of 14 subjects received no dietary intervention over a 4-week period. Platelet-monocyte aggregates were assessed with flow cytometry.Results: Dietary intervention with fish led to an increase in omega-3 fatty acids in plasma phospholipids (14.2 +/- 3.4% versus 5.8 +/- 1.3%, P < 0.001). In contrast to the control group, platelet-monocyte aggregates were reduced by 35% following dietary intervention with oily fish (16.0 +/- 9.0% versus 24.8 +/- 10.9%, P < 0.01), and returned to basal levels 4 weeks after discontinuation of supplementation. There was an inverse correlation between platelet-monocyte aggregation and plasma omega-3 fatty acid concentrations (r = -0.421, P = 0.006). There were no changes in the plasma markers of platelet activation, soluble P-selectin or soluble CD40 ligand.Conclusions: We have demonstrated, for the first time, that dietary intervention with oil-rich fish reduces platelet-monocyte aggregation in man. Our results suggest that reduced platelet activation provides a potential mechanism through which fish oils confer their cardiovascular preventative benefits. (C) 2007 Published by Elsevier Ireland Ltd.