A LONGITUDINAL-STUDY OF PRENATAL MARIJUANA USE - EFFECTS ON SLEEP AND AROUSAL AT AGE 3 YEARS
A LONGITUDINAL-STUDY OF PRENATAL MARIJUANA USE - EFFECTS ON SLEEP AND AROUSAL AT AGE 3 YEARS
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DOI：
10.1001/archpedi.1995.02170140027004
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发表时间：
1995-02-01
影响因子：
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通讯作者：
DAY, N
中科院分区：
文献类型：
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作者：
DAHL, RE;SCHER, MS;DAY, N
目的：为了验证这一假设，睡眠中断将是明显的，在3岁的儿童与产前marijuana exposure.Design的历史：一项前瞻性研究，采用分层随机抽样开始在怀孕的第四个月。通过在多个时间点进行访谈，对吸毒和其他物质使用情况进行了评估。在固定的时间点对后代进行多领域评估，包括新生儿期和3岁时的脑电图睡眠研究。设置：初级保健，一所大学医院的产前诊所。样本包括18名产前接触大麻的儿童（平均[+/-SD]年龄，39.0+/-4.4个月）和20名对照儿童（平均[+/-SD]年龄，39.7+/-4.4个月）。这两个组是相似的关系，母亲的年龄，种族，收入，教育，或母亲使用酒精，尼古丁，和其他物质在头三个月。主要结果测量：睡眠变量从多导睡眠图记录在3岁。结果：产前接触大麻的儿童表现出更多的夜间觉醒（平均值[+/-SD]，8.2+/-5.3 vs 3.2+/-4.6，P
Objective: To test the hypothesis that sleep disruptions would be evident in 3-year-old children with a history of prenatal marijuana exposure.Design: A prospective study using stratified random sampling beginning in the fourth month of pregnancy. Marijuana and other substance use were assessed by interviews at multiple time points. Offspring were followed up through age 3 years with multidomain assessments at fixed time points, including electroencephalographic sleep studies in the newborn period and at age 3 years.Setting: Primary care, prenatal clinic at a university hospital.Subjects: The sample included 18 children with prenatal marijuana exposure (mean [+/-SD] age, 39.0+/-4.4 months) and 20 control children (mean [+/-SD] age, 39.7+/-4.4 months). The two groups were similar in relationship to maternal age, race, income, education, or maternal use of alcohol, nicotine, and other substances in the first trimester.Main Outcome Measure: Sleep variables from polysomnographic recordings at age 3 years. Results: Children with prenatal;marijuana exposure showed more nocturnal arousals (mean [+/-SD], 8.2+/-5.3 vs 3.2+/-4.6, P