Do new and old biomarkers of early undifferentiated arthritis correlate with the Arthritis Impact Measurement Scales?
Do new and old biomarkers of early undifferentiated arthritis correlate with the Arthritis Impact Measurement Scales?
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DOI：
10.55563/clinexprheumatol/nqqx5k
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发表时间：
2021-01-01
影响因子：
3.7
通讯作者：
Marin, G.
中科院分区：
文献类型：
--
作者：
Bandinelli, F.;Benucci, M.;Marin, G.
目的在早期未分化关节炎(EUA)中，炎性生物标志物与残疾的关系尚不清楚。本研究旨在探讨炎性生物标志物与类风湿关节炎影响评定量表(AIMS)的相关性。通过非参数Spearman等级相关和Mann-Whitney U检验，分析AIMS[活动度、身体损害(PI)、灵巧性、家庭活动、日常生活能力(ADL)、社会活动、疼痛、焦虑、抑郁]与血清实验室[时相急性反应物、钙保护素、白介素6、肿瘤坏死因子(TNF)-α、类风湿因子、抗核和抗瓜氨酸肽抗体、HLA-DRB]、临床[疾病活动指数(CDAI)、疲劳、疼痛和僵硬NRS]、X射线和超声生物标志物之间的关系或在随访6个月时演变为早期RA的EUA患者(n=17)和仍保持EUA的患者(n=53)之间存在差异。在EUA组，血沉与活动障碍、PI、抑郁相关(P=0.022.0 4，P=0.0 3)，与PI相关(P=0.0 1)，与焦虑相关(P=0.0 2)。HLA-DRB1*11阳性的EUA患者日常生活能力缺乏(p=0.006)、抑郁(p=0.0004)和焦虑(p=0.0004)较低。CDAI与PI(p=0.0001)和疼痛(p=0.01)、疲劳与PI(p=0.0001)和日常生活能力(p=0.009)、僵硬与PI(p=0.11)、能量多普勒超声滑膜炎与PI(p=0.02)和疼痛(p=0.007)相关。HLA-DRB1*11阳性可能对这些疾病相关特征具有保护作用。
ObjectiveIn early undifferentiated arthritis (EUA), the relationship between inflammatory biomarkers and disability is still unclear. The aim of this study was to correlate inflammatory biomarkers with the Arthritis Impact Measurement Scales (AIMS) in EUA.MethodsSeventy patients with EUA were compared with 20 patients with established rheumatoid arthritis (RA). The association of AIMS [mobility, physical impairment (PI), dexterity, household activities, activities of daily living (ADL), social activity, pain, anxiety, depression] with serum laboratory [phase acute reactants, calprotectin, interleukin-6, tumour necrosis factor (TNF)-alpha, rheumatoid factor, anti-nuclear and anti-citrullinated peptide antibodies, HLA-DRB], clinical [Clinical Disease Activity Index (CDAI), fatigue, pain and stiffness NRS], x-ray and ultrasound biomarkers was analysed with non-parametric Spearman's rank correlation and Mann-Whitney U tests.ResultsNo differences in AIMS were found between EUA and established RA patients, or between EUA patients that evolved into early RA (n=17) and those that remained EUA (n=53) at six months of follow-up. In EUA, erythrocyte sedimentation rate correlated with mobility impairment, PI and depression (p=0.04, p=0.03 and p=0.022, respectively), TNF-alpha correlated with PI (p=0.01) and calprotectin with anxiety (p=0.02). HLA-DRB1*11-positive EUA patients had lower ADL deficiency (p=0.006), depression (p=0.0004) and anxiety (p=0.01). CDAI correlated with PI (p=0.01) and pain (p=0.01), fatigue with PI (p=0.0001) and ADL (p=0.009), stiffness with PI (p=0.(11), and Power Doppler ultrasound synovitis with PI (p=0.02) and pain (p=0.007).ConclusionIn EUA, physical and mood disorders are associated with new and old inflammatory serological, clinical and imaging biomarkers. HLA-DRB1*11-positivity may be protective against these disease-related features.