The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 repressor binding site.
The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 repressor binding site.
复制标题
酵母 UME6 基因产物是 CAR1 URS1 阻遏物结合位点介导的转录抑制所必需的。
DOI：
10.1093/nar/20.8.1909
复制
发表时间：
1992
影响因子：
14.9
通讯作者：
Cooper,TG
中科院分区：
文献类型：
--
作者：
Park,HD;Luche,RM;Cooper,TG
URS1是已知的酵母中的阻遏物结合位点，其负调节许多基因的表达，包括CAR1（脱氢酶），其中一些基因是孢子形成、交配型转换、肌醇代谢和氧化碳代谢所需的。除了先前显示的直接与URS1位点结合的蛋白质外，我们在此显示，在没有诱导剂的情况下，URS1需要UME 6基因产物来介导基因表达的抑制。我们还发现CAR80（CARGRI）基因突变与UME6基因突变是等位的。
URS1Is known to be a repressor binding site InSaccharomyces cerevisiaethat negatively regulates expression of many genes includingCAR1(arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. In addition to the proteins previously shown to directly bind to theURS1site, we show here that theUME6gene product is required forURS1to mediate repression of gene expression In the absence of Inducer. We also show that mutations in theCAR80(CARGRI) gene are allelic to those inUME6.