Coadministration of Seasonal Influenza Vaccine and MVA-NP+M1 Simultaneously Achieves Potent Humoral and Cell-Mediated Responses
Coadministration of Seasonal Influenza Vaccine and MVA-NP+M1 Simultaneously Achieves Potent Humoral and Cell-Mediated Responses
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DOI：
10.1038/mt.2013.162
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发表时间：
2014-01-01
影响因子：
12.4
通讯作者：
Gilbert, Sarah C.
中科院分区：
文献类型：
--
作者：
Antrobus, Richard D.;Berthoud, Tamara K.;Gilbert, Sarah C.
目前的季节性流感疫苗降低了免疫原性，对老年人的效果不佳。我们之前已经证明，新的候选疫苗MVA-NP+M1能够增强50-85岁成年人的记忆T细胞反应。临床前研究表明，当病毒载体疫苗与基于蛋白质的疫苗联合接种时，可以作为佐剂。我们已经进行了一项I期临床试验，以比较50岁及以上成年人联合接种季节性流感疫苗和MVA-NP+M1与单独接种季节性流感疫苗的情况。这种疫苗组合是安全的，耐受性良好。与只接种季节性流感疫苗的组相比，接受MVA-NP+M1的组T细胞对内部流感蛋白的反应显著增加。两组对三种疫苗株的血清保护率和血清转换率相似，但联合用药组季节性流感疫苗H3N2成分的几何平均滴度比显著增加。虽然一些疫苗组合会导致免疫干扰，但这里显示，MVA-NP+M1与季节性流感疫苗一起使用可以增加一些流感病毒株特异性抗体反应，并增强能够识别一系列甲型流感亚型的记忆T细胞。
Current seasonal influenza vaccines have reduced immunogenicity and are of suboptimal efficacy in older adults. We have previously shown that the novel candidate vaccine MVA-NP+M1 is able to boost memory T cell responses in adults aged 50-85 years. Preclinical studies have demonstrated that viral vectored vaccines can act as adjuvants when coadministered with protein-based vaccines. We have conducted a phase I clinical trial to compare the coadministration of seasonal influenza vaccine and MVA-NP+M1 with seasonal influenza vaccine alone in adults aged 50 years and above. This combination of vaccines was safe and well tolerated. T cell responses to internal influenza proteins were boosted to significantly higher levels in the group receiving MVA-NP+M1 compared with the group receiving seasonal influenza vaccine alone. Rates of seroprotection and seroconversion against the three vaccine strains were similar in both groups; however, there was a significant increase in the geometric mean titer ratio for the H3N2 component of seasonal influenza vaccine in the coadministration group. While some vaccine combinations result in immune interference, the coadministration of MVA-NP+M1 alongside seasonal influenza vaccine is shown here to increase some influenza strain-specific antibody responses and boost memory T cells capable of recognizing a range of influenza A subtypes.