Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases.
Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases.
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神经精神疾病的脑体细胞嵌合网络的基因组数据资源。
DOI：
10.1038/s41597-023-02645-7
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发表时间：
2023-11-20
期刊：
影响因子：
9.8
通讯作者：
Abyzov, Alexej
中科院分区：
文献类型：
--
作者：
Garrison, McKinzie A.;Jang, Yeongjun;Bae, Taejeong;Cherskov, Adriana;Emery, Sarah B.;Fasching, Liana;Jones, Attila;Moldovan, John B.;Molitor, Cindy;Pochareddy, Sirisha;Peters, Mette A.;Shin, Joo Heon;Wang, Yifan;Yang, Xiaoxu;Akbarian, Schahram;Chess, Andrew;Gage, Fred H.;Gleeson, Joseph G.;Kidd, Jeffrey M.;McConnell, Michael;Mills, Ryan E.;Moran, John V.;Park, Peter J.;Sestan, Nenad;Urban, Alexander E.;Vaccarino, Flora M.;Walsh, Christopher A.;Weinberger, Daniel R.;Wheelan, Sarah J.;Abyzov, Alexej
Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.
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影响因子：
7
作者：
Hosono, S;Faruqi, AF;Lasken, RS
通讯作者：
Lasken, RS
影响因子：
7
作者：
Eberle, Michael A.;Fritzilas, Epameinondas;Bentley, David R.
通讯作者：
Bentley, David R.
影响因子：
46.9
作者：
Dou, Yanmei;Kwon, Minseok;Park, Peter J.
通讯作者：
Park, Peter J.
影响因子：
64.8
作者：
Karczewski, Konrad J;Francioli, Laurent C;MacArthur, Daniel G
通讯作者：
MacArthur, Daniel G
影响因子：
9.8
作者：
Fromer, Menachem;Moran, Jennifer L.;Purcell, Shaun M.
通讯作者：
Purcell, Shaun M.