Enhancement of Synchronization Between Hippocampal and Amygdala Theta Waves Associated With Pontine Wave Density
Enhancement of Synchronization Between Hippocampal and Amygdala Theta Waves Associated With Pontine Wave Density
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DOI：
10.1152/jn.00551.2009
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发表时间：
2010-05-01
影响因子：
2.5
通讯作者：
Nakao, Mitsuyuki
中科院分区：
文献类型：
--
作者：
Karashima, Akihiro;Katayama, Norihiro;Nakao, Mitsuyuki
Karashima A，Katayama N，Nakao M.与脑桥波密度相关的海马区和杏仁核theta波的同步性增强。《神经生理学杂志》103：2318-2325,2010。2010年2月17日首次出版；DOI：10.1152/jn.00551.2009。杏仁核中的theta波与海马体中的theta波是同步的。在记忆提取过程中，杏仁核和海马theta波之间的同步被认为对这些区域之间的神经元通信非常重要。在快速眼动(REM)睡眠中也会观察到这些theta波。然而，很少有研究研究快速眼动睡眠中theta波的机制和功能。本研究探讨了大鼠在快速眼动睡眠过程中，海马区和杏仁核的动态变化与蓝斑下脑区脑桥(P)波的相关性，蓝斑下区激活了包括海马区和杏仁核在内的许多脑区。我们证实了海马theta波的频率随着P波密度的增加而增加，正如我们先前的研究所显示的那样。杏仁核theta波的频率也随着P波密度的增加而增加。此外，我们从互相关函数的角度证实了REM睡眠期间海马和杏仁核theta波之间的同步性，并发现这种同步性随着P波密度的增加而增强。我们通过损毁脑桥蓝斑下区域进一步研究了与P波密度相关的theta波同步。这种损伤不仅降低了海马和杏仁核的theta频率，而且还降低了theta波的同步性。这些结果表明，P波增强了区域theta波之间的同步性。因为已知海马体和杏仁核的theta波和P波参与学习和记忆过程，这些结果可能有助于阐明快速眼动睡眠中的这些功能。
Karashima A, Katayama N, Nakao M. Enhancement of synchronization between hippocampal and amygdala theta waves associated with pontine wave density. J Neurophysiol 103: 2318-2325, 2010. First published February 17, 2010; doi:10.1152/jn.00551.2009. Theta waves in the amygdala are known to be synchronized with theta waves in the hippocampus. Synchronization between amygdala and hippocampal theta waves is considered important for neuronal communication between these regions during the memory-retrieval process. These theta waves are also observed during rapid eye movement (REM) sleep. However, few studies have examined the mechanisms and functions of theta waves during REM sleep. This study examined correlations between the dynamics of hippocampal and amygdala theta waves and pontine (P) waves in the subcoeruleus region, which activates many brain areas including the hippocampus and amygdala, during REM sleep in rats. We confirmed that the frequency of hippocampal theta waves increased in association with P wave density, as shown in our previous study. The frequency of amygdala theta waves also increased with in associated with P wave density. In addition, we confirmed synchronization between hippocampal and amygdala theta waves during REM sleep in terms of the cross-correlation function and found that this synchronization was enhanced in association with increased P wave density. We further studied theta wave synchronization associated with P wave density by lesioning the pontine subcoeruleus region. This lesion not only decreased hippocampal and amygdala theta frequency, but also degraded theta wave synchronization. These results indicate that P waves enhance synchronization between regional theta waves. Because hippocampal and amygdala theta waves and P waves are known to be involved in learning and memory processes, these results may help clarify these functions during REM sleep.