Transcriptional delay stabilizes bistable gene networks.
Transcriptional delay stabilizes bistable gene networks.
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DOI：
10.1103/physrevlett.111.058104
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发表时间：
2013-08-02
影响因子：
8.6
通讯作者：
Bennett MR
中科院分区：
文献类型：
--
作者：
Gupta C;López JM;Ott W;Josić K;Bennett MR
转录延迟可以显著影响基因网络的动态。这里我们研究这种延迟如何影响双稳态系统。我们研究了几个双稳态基因网络的随机模型，发现延迟的增加显著地增加了接近稳定状态的平均停留时间。为了解释这一点，我们引入了一个非马尔可夫的、可解析处理的简化模型。该模型表明，稳定是稳定状态间过渡失败次数增加的结果。我们模拟的每一个双稳态系统都以这种方式运行。
Transcriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay dramatically increases the mean residence times near stable states. To explain this, we introduce a non-Markovian, analytically tractable reduced model. The model shows that stabilization is the consequence of an increased number of failed transitions between stable states. Each of the bistable systems that we simulate behaves in this manner.