CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): A focus on its role in cancer
CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): A focus on its role in cancer
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DOI：
10.1016/j.biocel.2015.03.007
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发表时间：
2015-05-01
影响因子：
4
通讯作者：
Chiquet-Ehrismann, Ruth
中科院分区：
文献类型：
--
作者：
Gurbuz, Irem;Chiquet-Ehrismann, Ruth
基质细胞蛋白WISP 1是CCN蛋白家族的成员。它由WNT 1诱导，是β-连环蛋白的下游靶点。WISP 1在胚胎发育、伤口愈合和组织修复过程中表达。异常WISP 1表达与包括骨关节炎、纤维化和癌症在内的多种病理学相关。它在肿瘤进展和临床结果中的作用使WISP 1成为检测和治疗肿瘤的新兴候选者。2015年，作者。由Elsevier Ltd.发布。这是CC BY-NC-ND许可下的开放获取文章。
The matricellular protein WISP1 is a member of the CCN protein family. It is induced by WNT1 and is a downstream target of beta-catenin. WISP1 is expressed during embryonic development, wound healing and tissue repair. Aberrant WISP1 expression is associated with various pathologies including osteoarthritis, fibrosis and cancer. Its role in tumor progression and clinical outcome makes WISP1 an emerging candidate for the detection and treatment of tumors. 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.