Lymphatic vessel invasion detected by monoclonal antibody D2-40 as a predictor of lymph node metastasis in T1 colorectal cancer
Lymphatic vessel invasion detected by monoclonal antibody D2-40 as a predictor of lymph node metastasis in T1 colorectal cancer
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DOI：
10.1007/s00384-009-0699-x
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发表时间：
2009-09-01
影响因子：
2.8
通讯作者：
Ito, I.
中科院分区：
文献类型：
--
作者：
Ishii, M.;Ota, M.;Ito, I.
在选择淋巴结转移高危患者时，检测淋巴管浸润（LVI）非常重要。本研究采用D2-40染色法检测LVI作为T1期结直肠癌淋巴结转移的预测指标，对136例T1期结直肠癌患者行结肠切除联合淋巴结清扫术，并对LVI等临床病理因素进行分析。我们用单克隆抗体D2-40免疫组化法检测LVI，发现18例（13.2%）患者有淋巴结转移，45例（33%）患者有LVI，LVI阳性组中淋巴结转移率更高（13/45 vs 5/91，p < 0.001）。单因素和多因素分析显示，D2-40检测的LVI和浸润前沿组织学分化差是淋巴结转移的独立危险因素，D2-40检测的LVI对预测淋巴结转移有重要意义。
When selecting patients who are at high risk for lymph node metastasis, the detection of lymphatic vessel invasion (LVI) is important. We investigated LVI detected by D2-40 staining as a predictor of lymph node metastasis in T1 colorectal cancer.Clinicopathological factors including LVI were investigated in 136 patients who underwent colectomy with lymph node dissection for T1 colorectal cancer. We used immunostaining with monoclonal antibody D2-40 to detect LVI.Lymph node metastases were found in 18 patients (13.2%), and LVI were detected in 45 (33%); lymph node metastasis was more frequently observed in LVI-positive groups (13/45 vs 5/91, p < 0.001). Both univariate and multivariate analyses revealed that LVI detected by D2-40 and a poorly differentiated histology at the invasion front were independent risk factors of lymph node metastasis.LVI detected by D2-40 is important for the prediction of lymph node metastasis.