The epidemiology of osteoarthritis
The epidemiology of osteoarthritis
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DOI：
10.1016/j.berh.2014.01.004
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发表时间：
2014-02-01
影响因子：
5.2
通讯作者：
Hunter, David J.
中科院分区：
文献类型：
--
作者：
Johnson, Victoria L.;Hunter, David J.
骨关节炎（OA）是导致残疾的主要原因，由于肥胖和人口老龄化，其发病率正在上升。危险因素可分为个人水平因素，如年龄、性别、肥胖、遗传、种族/民族和饮食，以及关节水平因素，包括损伤、关节错位和异常负荷。这些危险因素的相互作用是复杂的，并提供了一个挑战的管理医生。本综述的目的是阐明这些因素是如何相互作用以引发偶发性OA的，并概述对未来预防偶发性OA和进行性OA进行流行病学研究的必要性。只有了解这种疾病的影响和可改变的风险因素，我们才能真正有针对性地采取适当的公共卫生预防干预措施。(C) 2014 Elsevier Ltd.版权所有。
Osteoarthritis (OA) is a leading cause of disability and its incidence is rising due to increasing obesity and an ageing population. Risk factors can be divided into person-level factors, such as age, sex, obesity, genetics, race/ethnicity and diet, and joint-level factors including injury, malalignment and abnormal loading of the joints. The interaction of these risk factors is complex and provides a challenge to the managing physician. The purpose of this review is to illustrate how each of these factors interact together to instigate incident OA as well as to outline the need for ongoing epidemiologic studies for the future prevention of both incident and progressive OA. It is only by understanding the impact of this disease and the modifiable risk factors that we will be able to truly target public health prevention interventions appropriately. (C) 2014 Elsevier Ltd. All rights reserved.