The Pathogenesis of Persistent Turbinate Atrophy Induced by Toxigenic Pasteurella multocida in Pigs
The Pathogenesis of Persistent Turbinate Atrophy Induced by Toxigenic Pasteurella multocida in Pigs
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产毒多杀性巴氏杆菌致猪持续性鼻甲萎缩的发病机制
DOI：
10.1177/030098588502200506
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发表时间：
1985
影响因子：
2.4
通讯作者：
K. Pedersen
中科院分区：
文献类型：
--
作者：
F. Elling;K. Pedersen
用1%乙酸溶液在一个或两个鼻孔中预处理六只一周龄仔猪两天。3头仔猪未接受乙酸处理。给药后3天，所有9头仔猪均在两个鼻孔中接种多杀性巴氏杆菌的致突变D型菌株。接种后7天处死3头仔猪; 1头在接种后13天自发死亡，其余猪在约90 kg体重时处死，即，五到六个月大所有乙酸处理动物的处理鼻孔中的鼻甲均出现重度萎缩。未处理的鼻孔正常。本研究结果表明，致炎性多杀性巴氏杆菌可引起鼻甲骨萎缩，并持续至90 kg体重时，其病变类似于猪的自发性萎缩性鼻炎。鼻甲萎缩不伴有炎症反应、其他骨结构萎缩或其他器官病变。实验还表明，致炎性多杀性巴氏杆菌可能存在于对照动物的扁桃体中，而不会引起鼻甲萎缩。提出了猪萎缩性鼻炎的发病机理。
Six one-week-old piglets were pretreated with a 1% acetic acid solution for two days in one or both nostrils. Three piglets were not treated with acetic acid. Three days after treatment all nine piglets were inoculated in both nostrils with a toxigenic type D strain of Pasteurella multocida. Three piglets were killed seven days after inoculation; one died spontaneously 13 days after inoculation and the remaining pigs were killed at approximately 90 kg body weight, i.e., five to six months of age. All acetic acid-treated animals developed severe atrophy of the turbinates in the treated nostrils. Untreated nostrils were normal. The present results showed that toxigenic P. multocida can induce turbinate atrophy that persisted until 90 kg body weight when the lesions were similar to spontaneous atrophic rhinitis in pigs. The turbinate atrophy was not accompanied by inflammatory reaction, atrophy of other bone structures, or lesions in other organs. The experiment showed furthermore that toxigenic P. multocida may be present in the tonsils of control animals without causing turbinate atrophy. A pathogenesis for atrophic rhinitis in pigs is proposed.