Distress vocalizations in infant rats: What's all the fuss about?
Distress vocalizations in infant rats: What's all the fuss about?
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DOI：
10.1111/1467-9280.00219
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发表时间：
2000-01-01
影响因子：
8.2
通讯作者：
Kent, KJ
中科院分区：
文献类型：
--
作者：
Blumberg, MS;Sokoloff, G;Kent, KJ
由幼年啮齿动物发出的超声波发声通常以痛苦的哭声为特征。已知有两种情况可以可靠地诱发超声波产生，极端寒冷暴露和可乐定（一种α 2肾上腺素受体激动剂）给药。注意到这两种情况都需要显著降低不良心率，我们假设发声是生理动作的声学副产品;腹部压迫反应（ACR），当返回受损时增加静脉返回心脏。作为这一假设的一个关键检验，我们测量了可乐定给药后15日龄大鼠右心房附近的静脉压。与ACR假设一致，超声发射伴随着静脉压和静脉回流的大而可靠的增加。这些结果为ACR假说提供了强有力的直接支持，并通过这样做，强调了拟人化解释幼鼠发声的潜在陷阱。
Ultrasonic vocalizations emitted by infant rodents are typically characterized as cries of distress. There are two contexts that are known to reliably elicit ultrasound production extreme cold exposure and administration of clonidine, an alpha(2) adrenoreceptor agonist. Noting that these two contexts both entail pronounced decreases ill cardiac rate, we have hypothesized that the vocalizations are acoustic by-products of a physiological maneuver; the abdominal compression reaction (ACR), that increases venous return to the heart when return is compromised. As a critical test of this hypothesis, we measured venous pressure near the right atrium in 15-day-old rats after clonidine administration. Consistent with the ACR hypothesis, emission of ultrasound was accompanied by large and reliable increases in venous pressure and, therefore, venous return. These results provide strong, direct support for the ACR hypothesis and, by doing so, underscore the potential pitfalls of anthropomorphic interpretations of the vocalizations of infant rats.